|
Cerebral Amyloid Angiopathy
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of the Amyloid Precursor Protein, present in chromosome 21, leads to β-amyloid deposition that results in Alzheimer disease (AD) and, in most cases, also to cerebral amyloid angiopathy (CAA) neuropathology.
|
31278851 |
2019 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
We report here that a single intravenous injection of an Alzheimer disease patient's-brain extract into APP/PS1 recipient mice led to cerebral amyloid angiopathy within 180 days post injection.
|
29506560 |
2018 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we have compared the severity of amyloid plaque formation and cerebral amyloid angiopathy (CAA), and the subtype pattern of CAA pathology itself, between APP genetic causes of AD (APPdup, APP mutations), older individuals with Down syndrome (DS) showing the pathology of Alzheimer's disease (AD) and individuals with sporadic (early and late onset) AD (sEOAD and sLOAD, respectively).
|
29770843 |
2018 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We suggest that the clinical presentation in DS (prominent memory decline and behavioral symptoms, and early development of myoclonus and seizures) are similar to the clinical features associated with APP mutations that is known to have an increased Aβ42/ Aβ40 ratio, and highlight the relative lack of vascular complications associated with cerebral amyloid angiopathy in DS in comparison with those rare individuals with FAD due to duplication APP.
|
28870521 |
2018 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) caused by a point mutation resulting in an amino acid change (NP_000475.1:p.Glu693Gln) in the amyloid precursor protein (APP).
|
29706885 |
2018 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review.
|
27858710 |
2017 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
According to the literature, the APP Ala713Thr mutation is associated with Alzheimer's disease and cerebral amyloid angiopathy.
|
28304299 |
2017 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
Female APP/PS1 mice had more severe cerebral amyloid angiopathy and subsequent microhemorrhage.
|
26707129 |
2016 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy.
|
25828868 |
2016 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.
|
26556230 |
2015 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
Biochemically, deposition of the β-amyloid (Aβ) peptides produced from proteolytic processing of APP forms the defining pathological hallmark of AD; genetically, both point mutations and duplications of wild-type APP are linked to a subset of early onset of familial AD (FAD) and cerebral amyloid angiopathy.
|
22355794 |
2012 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.
|
22116809 |
2012 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No evidence of APP point mutation and locus duplication in individuals with cerebral amyloid angiopathy.
|
21463452 |
2011 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
CTD_human |
Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells.
|
21520056 |
2011 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that lack of apoA-I aggravates the memory deficits in APP/PS1ΔE9 mice in parallel to significantly increased cerebral amyloid angiopathy.
|
20739292 |
2010 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
Biomarker
|
disease |
LHGDN |
Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy.
|
19139910 |
2009 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The occurrence of duplications of the amyloid precursor protein gene (APP) has been described in European families with early-onset familial Alzheimer disease (EO-FAD) and cerebral amyloid angiopathy.
|
19684239 |
2009 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cerebral amyloid angiopathy (CAA), characterized by extracellular beta-amyloid peptide (Abeta) deposits in vessel walls, is present in the majority of cases of Alzheimer's disease and is a major cause of hemorrhagic stroke.
|
19457117 |
2009 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Positron emission tomography with 11C-PiB and magnetic resonance imaging were performed for 2 patients, 49-year-old and 60-year-old siblings with APP locus duplication, with hereditary Alzheimer disease and cerebral amyloid angiopathy.
|
18413480 |
2008 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One Swedish case and 1 American case with the Arctic APP mutation came to autopsy, and both showed no signs of hemorrhage but revealed severe congophilic angiopathy, region-specific neurofibrillary tangle pathological findings, and abundant amyloid plaques.
|
18413473 |
2008 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
|
18413480 |
2008 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The apoE4 targeted replacement mice do not harbor any mutation in the amyloid precursor protein gene and, therefore, are similar to the majority of humans susceptible to cerebral amyloid angiopathy and ICH, where the APOE genetic polymorphism is the only known genetic risk factor.
|
18755411 |
2008 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
|
16369530 |
2006 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Alzheimer's disease (AD) is characterized by pathological lesions, such as senile plaques (SPs) and cerebral amyloid angiopathy (CAA), both predominantly consisting of a proteolytic cleavage product of the amyloid-beta precursor protein (APP), the amyloid-beta peptide (Abeta).
|
16485107 |
2006 |
|
Cerebral Amyloid Angiopathy
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Cerebral amyloid angiopathy (CAA) is characterized by the degeneration of cerebral microvascular smooth muscle cells (MV-SMC) and the replacement of normal vessel wall components by beta-amyloid (Abeta) protein.
|
16783171 |
2006 |