|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Administration of PPARA agonists decreases amyloid pathology and reverses memory deficits and anxiety symptoms in APP-PSEN1ΔE9 mice.
|
30898012 |
2020 |
|
Memory impairment
|
0.500 |
GeneticVariation
|
phenotype |
BEFREE |
In this report, we found that a PSEN1 mutation (S169del) altered APP processing and Aβ generation, and promoted neuritic plaque formation as well as learning and memory deficits in AD model mice.
|
29915376 |
2020 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Here, we investigated the roles of NDRG2 in the development of memory impairment in AD using mouse models established by amyloid β injection or crossing of APP/PS1 mice.
|
31778735 |
2020 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Importantly, APP/PS1/δ<sup>D910A</sup> mice exhibited no spatial learning or memory deficits.
|
31363064 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
First, silibinin and silymarin administration could alleviate memory deficits and reduce the amyloid plaque burden in the brain of APP/PS1 mice in comparison with controls.
|
31236617 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Restraint/isolation stress induced significant depressive-like behaviors in APP/PS1 mice at 4 months of age and memory impairment at 10 months of age, while 6 months of icariin administration relieved the memory damage.
|
31001073 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse.
|
31551717 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Behavioral tests further confirmed PTS' potential of overcoming memory deficits in APP/PS1 mice (AD model).
|
31737188 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
MCH improved memory impairment in both models and reduced soluble amyloid beta in the cerebral cortex of APP/PS1 transgenic mice.
|
31183806 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Here, we tested whether dietary choline supplementation throughout life reduces AD-like pathology and rescues memory deficits in the APP/PS1 mouse model of AD.
|
31560162 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
The spatial learning and memory deficit from the 8-month-old APP/PS1 mice was observed in the Y-maze test and fear conditioning task.
|
31286344 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
We show that treatment aimed at preventing PV interneurons from becoming hyperexcitable is sufficient to restore PV interneuron properties to wild-type levels, reduce inhibitory input onto pyramidal cells, and rescue memory deficits in APP/PS1 mice.
|
31431685 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
TEN has potential benefit in treating learning and memory deficits in APP/PS1 transgenic AD mice, and its effects may be associated with reversing AD pathology-induced neuronal apoptosis.
|
31664284 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Treatment with the active compounds reduced cognitive and memory deficits and damaged cell ultrastructure in APP/PS1 mice.
|
31816602 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway.
|
30774310 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
It was also demonstrated pro-neurogenesis effects in ICR and APP/PS1 mice and improved memory deficit of APP/PS1 mice.
|
31257716 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
In this study, we sought to determine the molecular correlates of memory deficits in APP/PS1 mice, a widely used animal model of Alzheimer's disease.
|
31585361 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, Inhibiting JAK2/STAT3 significantly rescued the memory deficits and hippocampal neurogenesis dysfunction in APP/PS1 mice.
|
30763768 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Treatment with lentivirus-mediated overexpression of miR-124 or the C1q inhibitor C1INH rescued breakdown of blood-brain barrier, promoted angiogenesis and reduced Aβ deposition, and finally alleviated learning and memory deficit in APP/PS1 mice.
|
31499089 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Moreover, JuA suppresses SD-induced enhancement of mEPSCs and prevents memory impairment in APP/PS1 mice.
|
30872728 |
2019 |
|
Memory impairment
|
0.500 |
AlteredExpression
|
phenotype |
BEFREE |
Our results showed that over-expression of mutant human APP gene in the hippocampus led to learning and memory deficits concomitant with gliosis and pro-inflammatory responses.
|
31233762 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.
|
30871577 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Soluble forms of beta amyloid peptide (Aβ) have been implicated both in the development of early memory deficits and neuropsychiatric symptoms.
|
31156428 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
Moreover, while promoting apoE interaction with APP by ApoEp exacerbated Aβ and tau brain pathologies in 3XTg-AD mice, disrupting this interaction by 6KApoEp ameliorated cerebral Aβ and tau pathologies, neuronal apoptosis, synaptic loss, and hippocampal-dependent learning and memory impairment in 5XFAD mice without altering cholesterol, low-density lipoprotein receptor, and apoE expression levels.
|
31208706 |
2019 |
|
Memory impairment
|
0.500 |
Biomarker
|
phenotype |
BEFREE |
We demonstrated that MSe-Res/Fc-β-CD/Bor inhibited aggregation of β-amyloid proteins (Aβ), mitigated oxidative stress, and suppressed tau hyperphosphorylation, while protecting nerve cells and successfully improving memory impairment in APP/PS1 mice.
|
30638753 |
2019 |