Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mid infrared light treatment attenuates cognitive decline and alters the gut microbiota community in APP/PS1 mouse model.
|
31831179 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology.
|
31783135 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results showed that tan IIA significantly ameliorates cognitive deficits and improves spatial learning ability of APP/PS1 mice in the nest-building test, novel object recognition test and Morris water maze test.
|
31778727 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results exhibited that CB treatment prevented cognitive impairment, Aβ deposits, microglia activation and production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the brain of APP/PS1 mice.
|
31835282 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
The APP/PS1 mice began to show cognitive decline at 3 months of age and MCT4 in the hippocampus of 2- and 3-month old APP/PS1 mice was higher than that of C57 mice.
|
31738978 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice.
|
31839610 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
The consumption of BB modulates the expression of proteins that are linked to the improvements of cognitive dysfunction in hippocampus of APP/PS1 transgenic mice.
|
29781405 |
2020 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dengzhan Shengmai capsules and their active component scutellarin prevent cognitive decline in APP/PS1 mice by accelerating Aβ aggregation and reducing oligomers formation.
|
31810113 |
2020 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that phenotypes for onset and rate of cognitive decline vary with PSEN1 and APP genes, suggesting a behavioral heterogeneity in ADAD.
|
31386938 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of silibinin on β-secretase levels, Aβ enzymatic degradation, and oxidative stress in the brains of APP/PS1 mice with cognitive impairments.
|
31087219 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the mechanisms that Aβ-blocked extracellular space (ECS) induces memory disorders in APP/PS1 transgenic mice and addressed whether red light (RL) at 630 nm rescues cognitive decline by reducing Aβ-disturbed flow of interstitial fluid (ISF).
|
31720368 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because β-amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27-OHC could lead to cognitive impairment through modulating Aβ accumulation and deposition.
|
30582229 |
2019 |
Impaired cognition
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Importantly, SNX8 overexpression rescued cognitive impairment in APP/PS1 mice.
|
31551717 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease.
|
31816602 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects.
|
30610438 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
No significant difference was found between the APP/PS2 and wild-type mice at 2-6 months of age in terms of novel object recognition memory; subsequently, however, APP/PS2 mice showed a clear cognitive deficit at 12 months of age.
|
30047036 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice.
|
31190768 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, markedly reduced cognitive impairment in APP/PS1 mice and oAβ<sub>1-42</sub>-injected mice.
|
30537634 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Walnut-Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice.
|
31237989 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice.
|
30504006 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gallic acid disruption of Aβ<sub>1-42</sub> aggregation rescues cognitive decline of APP/PS1 double transgenic mouse.
|
30447302 |
2019 |
Impaired cognition
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion</b>: These results suggest that UTI inhibits neuronal apoptosis in rat brain by attenuating increased expression of Aβ<sub>42</sub> and inflammatory cytokines, which may contribute to its alleviation of isoflurane-induced cognitive dysfunction in rats.
|
31311447 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss.
|
31685977 |
2019 |
Impaired cognition
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease.
|
30795807 |
2019 |
Impaired cognition
|
0.600 |
Biomarker
|
disease |
BEFREE |
Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice.
|
30374941 |
2019 |