APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Mid infrared light treatment attenuates cognitive decline and alters the gut microbiota community in APP/PS1 mouse model. 31831179 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Notopterygium incisum extract (NRE) rescues cognitive deficits in APP/PS1 Alzhneimer's disease mice by attenuating amyloid-beta, tau, and neuroinflammation pathology. 31783135 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Our results showed that tan IIA significantly ameliorates cognitive deficits and improves spatial learning ability of APP/PS1 mice in the nest-building test, novel object recognition test and Morris water maze test. 31778727 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Our results exhibited that CB treatment prevented cognitive impairment, Aβ deposits, microglia activation and production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the brain of APP/PS1 mice. 31835282 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE The APP/PS1 mice began to show cognitive decline at 3 months of age and MCT4 in the hippocampus of 2- and 3-month old APP/PS1 mice was higher than that of C57 mice. 31738978 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. 31839610 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE The consumption of BB modulates the expression of proteins that are linked to the improvements of cognitive dysfunction in hippocampus of APP/PS1 transgenic mice. 29781405 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Dengzhan Shengmai capsules and their active component scutellarin prevent cognitive decline in APP/PS1 mice by accelerating Aβ aggregation and reducing oligomers formation. 31810113 2020
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 GeneticVariation disease BEFREE These results suggest that phenotypes for onset and rate of cognitive decline vary with PSEN1 and APP genes, suggesting a behavioral heterogeneity in ADAD. 31386938 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE In this study, we investigated the effect of silibinin on β-secretase levels, Aβ enzymatic degradation, and oxidative stress in the brains of APP/PS1 mice with cognitive impairments. 31087219 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE In this study, we investigated the mechanisms that Aβ-blocked extracellular space (ECS) induces memory disorders in APP/PS1 transgenic mice and addressed whether red light (RL) at 630 nm rescues cognitive decline by reducing Aβ-disturbed flow of interstitial fluid (ISF). 31720368 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Because β-amyloid peptide () is the pathological hallmark of AD, the aim of this study is to verify whether 27-OHC could lead to cognitive impairment through modulating accumulation and deposition. 30582229 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 AlteredExpression disease BEFREE Importantly, SNX8 overexpression rescued cognitive impairment in APP/PS1 mice. 31551717 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease. 31816602 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects. 30610438 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE No significant difference was found between the APP/PS2 and wild-type mice at 2-6 months of age in terms of novel object recognition memory; subsequently, however, APP/PS2 mice showed a clear cognitive deficit at 12 months of age. 30047036 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Long-term icariin treatment ameliorates cognitive deficits via CD4<sup>+</sup> T cell-mediated immuno-inflammatory responses in APP/PS1 mice. 31190768 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, markedly reduced cognitive impairment in APP/PS1 mice and oAβ<sub>1-42</sub>-injected mice. 30537634 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Walnut-Derived Peptide PW5 Ameliorates Cognitive Impairments and Alters Gut Microbiota in APP/PS1 Transgenic Mice. 31237989 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice. 30504006 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Gallic acid disruption of Aβ<sub>1-42</sub> aggregation rescues cognitive decline of APP/PS1 double transgenic mouse. 30447302 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 AlteredExpression disease BEFREE <b>Conclusion</b>: These results suggest that UTI inhibits neuronal apoptosis in rat brain by attenuating increased expression of <sub>42</sub> and inflammatory cytokines, which may contribute to its alleviation of isoflurane-induced cognitive dysfunction in rats. 31311447 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss. 31685977 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 GeneticVariation disease BEFREE Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer's disease. 30795807 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.600 Biomarker disease BEFREE Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice. 30374941 2019