Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
|
31678156 |
2020 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice, but also significantly contributed to severe memory loss in aged APP/PS1 mice.
|
31321704 |
2019 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
More importantly, the Pt<sup>II</sup> -PW<sub>11</sub> greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment.
|
31591753 |
2019 |
Memory Loss
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Somatostatin (SST) blocks the aggregation of Aβ and inflammation whereas reduction of SST levels in the CSF and brain tissue is associated with impaired cognitive function and memory loss.
|
29700775 |
2019 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Here, we use the J20-APP AD mouse model that displays spatial memory loss as well as reduced slow gamma amplitude and phase-amplitude coupling to theta oscillations phase.
|
31757962 |
2019 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to β-Amyloid peptide accumulation.
|
28801921 |
2018 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat.
|
29729307 |
2018 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.
|
27457810 |
2017 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
|
28448946 |
2017 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Three months of treatment of AAV9-GFP-CIP reduced pathologic changes, including τ hyperphosphorylation, (Aβ) deposit, astrocytosis, and microgliosis, which were correlated with the reversal of memory loss and anxiety-like behavior observed in APP/PS1 mice.
|
28420695 |
2017 |
Memory Loss
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Treatment of 3xTg-AD mice with flavocoxid reduced: (1) learning and memory loss; (2) the increased eicosanoid production and the phosphorylation level of amyloid precursor protein (APP-pThr668), Aβ 1-42, p-tau (pThr181), pERK, and the activation of the NLRP3 inflammasome; (3) Aβ plaques; and (4) neuronal loss, compared to saline-treated animals.
|
28238167 |
2017 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
APP/PS1 double-transgenic mice treated with 3F5 mAb showed reduced memory loss, cognitive decline, and decreased levels of amyloid deposits in the brain.
|
28662102 |
2017 |
Memory Loss
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention.
|
27388605 |
2016 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
[Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats.
|
27306655 |
2016 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age.
|
26480858 |
2016 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway.
|
26420483 |
2015 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice.
|
25881725 |
2015 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
|
24858312 |
2014 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation.
|
25213453 |
2014 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.
|
23827522 |
2013 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats.
|
22484447 |
2012 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The amyloid precursor protein (APP) and its cleavage product Aβ play central roles in synapse and memory loss, and thus are strongly implicated in the pathogenesis of AD.
|
21199446 |
2012 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss.
|
22042871 |
2011 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Functionally, removing CX3CR1 in human amyloid precursor protein mice worsened the memory retention in passive avoidance and novel object recognition tests, and their memory loss in the novel object recognition test is associated with high levels of interleukin 6.
|
21771791 |
2011 |
Memory Loss
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The brain formaldehyde level in APP/PS1-transgenic (n=8) mice at age of 3 months and APP-transgenic (n=8) mice at age of 6 months was increased (0.56 ± 0.02 mM), respectively, as compared with their respective age-matched controls, when these two types of AD-like animals, respectively, started to form Aβ deposits and memory loss obviously.
|
19879019 |
2011 |