KLK3, kallikrein related peptidase 3, 354

N. diseases: 358; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Impact of total PSA and percent free PSA in the differentiation of prostate disease: a retrospective comparative study implicating neoplastic and non-neoplastic entities. 31786882 2020
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE The serum prostate specific antigen is the most widespread biomarker for prostate disease. 31833333 2019
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Urologists must appreciate the effects of drugs provided for other diseases on PSA titers and be aware that sudden changes may not reflect underlying prostatic disease. 30370673 2019
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE The neutrophil/lymphocyte ratio did not discriminate between benign and malignant prostatic disease in patients with a PSA between 4-10ng/ml. 31759363 2019
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Trichomonas vaginalis infection and prostate-specific antigen concentration: Insights into prostate involvement and prostate disease risk. 31376187 2019
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Currently prostate-specific antigen is used for prostate cancer (PCa) screening, however it lacks the necessary specificity for differentiating PCa from other diseases of the prostate such as benign prostatic hyperplasia (BPH), presenting a clinical need to distinguish these cases at the molecular level. 29695737 2018
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Men with a history of PC, radical prostatectomy or a "monitoring" PSA test for prostate disease were excluded. 29523809 2018
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE The outcome factor was ordering an "asymptomatic" PSA test (a PSA ordered for an indication that was not prostate-related symptoms or prostatic disease monitoring). 28869684 2017
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Mean total PSA, free PSA, and free-total PSA ratio levels of quarry workers did not differ from those of controls and was below the cutoff for the risk of prostate diseases. 27362426 2017
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Current prostate cancer (PCa) biomarkers such as PSA are not optimal in distinguishing cancer from benign prostate diseases and predicting disease outcome. 25686826 2015
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Nonetheless, PSA shows weakness in discriminating between malign and benign prostatic disease or indolent and aggressive cancers. 24825472 2014
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Prostate specific antigen (PSA) is the best-known member of the kallikrein-related peptidase family, with an established role as a prostatic disease biomarker. 21394741 2011
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE Prostate-specific antigen (PSA) is a serum marker that is widely used for the diagnosis of prostatic diseases. 22019475 2011
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE PSA, as its name implies, is not specific for prostate cancer and as such is often found elevated in other prostatic diseases/symptoms associated with the aging male. 19507229 2009
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 GeneticVariation group LHGDN Genetic variations in the PSA promoter are associated with serum PSA levels in men without prostatic disease. 12865450 2003
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 AlteredExpression group BEFREE Genetic variations in the PSA promoter are associated with serum PSA levels in men without prostatic disease. 12865450 2003
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE To evaluate the diagnostic utility of free PSA (fPSA) and complexed PSA forms for identification of men with PCa in the low PSA range of <4 microg/l, total PSA (tPSA), alpha(1)-antichymotrypsin complexed PSA (PSA-ACT) and fPSA (Roche Elecsys [ES] system) as well as tPSA and complexed PSA (cPSA) (Bayer Immuno 1 system) were measured in archival serum samples from 31 untreated patients with PCa, 66 patients with BPH, and 90 men without prostatic disease. 11477592 2001
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE To further elucidate the factors affecting the serum levels of this important tumor marker, we measured PSA concentrations in serum and in aspiration biopsies (tissue PSA; T-PSA) from patients with prostatic disease and correlated the values to tumor stage, cytological grade, and DNA ploidy. 10068342 1999
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases
0.100 Biomarker group BEFREE However, serum PSA concentrations can be successfully used together with other methods in diagnosing prostatic diseases and in monitoring the successfulness of treatments for prostatic cancer. 7521173 1994