|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings established a link between monocyte-like CD163-MNPs, IL-12, IL-1β and the detection of colonic memory IL-8-producing CD4+T cells, which might all contribute to UC pathogenesis.
|
31206576 |
2020 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The activation of A3AR by 2-Cl-IB-MECA significantly decreased TNF-α and IL-1β production and attenuated the NF-κB p65 activation in colonic tissues from patients with UC.
|
31714673 |
2020 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We recently demonstrated a role for IgG and Fcγ receptor signalling in driving pathogenic IL-1β production by colonic mononuclear phagocytes and the subsequent induction of a local type 17 response in UC.
|
31480888 |
2019 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Oscillibacter abundance was significantly positively correlated with IL-6 and IL-1β levels and pathological score, and Oscillibacter was increased in UC mice.
|
31689519 |
2019 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A Polymorphism in Interleukin-1β Gene Is Associated with the Development of Pouchitis in Japanese Patients with Ulcerative Colitis.
|
31671425 |
2019 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS.
|
30797423 |
2019 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In vitro studies revealed that <i>Trim58</i><sup>-/-</sup> myeloid cells, which showed constitutive upregulation of TLR2 protein, overreacted to a proinflammatory milieu (TNF-α and IFN-γ) with increased IL-1β protein production, which mechanistically depended on <i>Tlr2</i> Finally, we found that TRIM58 mRNA and protein expression levels were reduced in colonic specimens from patients with ulcerative colitis.
|
31383741 |
2019 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05).
|
30906449 |
2019 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo manipulation of macrophage FcγR signal strength in a mouse model of UC determined the magnitude of intestinal inflammation and IL-1β-dependent type 17 immunity.
|
30876876 |
2019 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL1R2, which encodes IL-1 receptor type 2 (IL-1R2), was reported as a risk gene for UC.
|
29366788 |
2018 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We concluded that serum IL-1β and IL-1ra and to a lesser extend stool IL-1β concentrations may be useful prognostic factors in children with active and inactive UC over a short-term follow-up period, which may help to identify children that require more aggressive therapy due to an increased risk of relapse or complications resulting from UC.
|
29379540 |
2018 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, qRT-PCR, immunohistochemistry, immunofluorescence confocal microscopy were used to (1) assess the mRNA expression of <i>NLRP3, IL-1β, CASP1</i> and <i>ASC</i> in paired biopsies from UC and CD patient, and (2) the colonic localization and spatial relationship of NLRP3 and IL-1β in active and quiescent disease.
|
30583612 |
2018 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
By attracting additional immune cells, as well as inducing proinflammatory IL-1β release from immune cells, CCL20 may protract the inflammatory response in ulcerative colitis.
|
30347808 |
2018 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IELs secreted significantly increased IL-1β in patients with UC, significantly increased IL-17A and IFN-γ in patients with CD, and significantly increased TNF-α in patients with CD and axSpA as compared to other cohorts.
|
30029674 |
2018 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We show that neutrophil expression of REDD1 in colon tissue and the presence of IL-1β in neutrophils/NETs provide candidate biomarkers for the differential diagnosis of inflammatory colitis and possible targets for the treatment of UC, suggesting that UC shares common features with autoinflammatory disorders.
|
29712770 |
2018 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, uninflamed ileum also showed increased IL-6 and IL-1β levels in UC-New subgroups.
|
27622899 |
2017 |
|
Ulcerative Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We found that the patients suffered ulcerative colitis had high serum SDC1 levels,presented with increased levels of P65, tumour necrosis factor alpha (TNF-α) and IL-1β and higher circulating neutrophils.
|
27558380 |
2017 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The NLRP3 inflammasome-derived IL-1β and IL-18 may play a protective role against UC through different mechanisms.
|
27966619 |
2016 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, our results reveal that the IL-1/IL-1R2 axis is differentially regulated in the remitting intestinal mucosa of UC patients.
|
26530134 |
2016 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
IL-1β -511 CC genotype was significantly less present in UC compared to controls, while IL-1RA Mspa-I11100 CC was significantly associated with both Crohn's disease (CD) and ulcerative colitis (UC).
|
25466956 |
2015 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
RGD |
"[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]."
|
24812904 |
2014 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Invasiveness of intracellular E. coli strains into the intestinal mucosa and IL-1β production may contribute to CD and UC pathogenesis.
|
24581881 |
2014 |
|
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Baseline serum concentrations of TNF and IL1β were higher in UC patients than in CD patients (p = 0.0097 and 0.0024, respectively).
|
22960943 |
2013 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mucosal biopsies from CC (n=10), LC (n=5), and CC or LC patients in histopathological remission (CC-HR, n=4), (LC-HR, n=6), ulcerative colitis (UC, n=3) and controls (n=10) were analysed by real-time PCR and Luminex for expression/production of IL-1β, -4, -5, -6, -10, -12, -17, -21, -22, -23, IFN-γ, TNF-α, T-bet and RORC2.
|
23566938 |
2013 |