Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further, meta-analysis revealed significant association of IL-1β rs1143627: T > C (p = 0.026; OR = 4.165; 95% CI 1.18-14.65) and rs16944: C > T (p = 0.01; OR = 5.49; 95% CI 1.48-20.37) in presence of H. pylori with gastric cancer in Asian population though no significant difference (p > 0.05) was found when compared to absence of H. pylori .
|
30094865 |
2018 |
Malignant neoplasm of stomach
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IFN-γ and IL-10 levels were significantly higher in early (I/II) and late stage (III/IV) gastric cancer; IL-1β and IL-8 were higher and MCP-1 was lower only in late stage (IV) patients.
|
28558708 |
2017 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The pro-inflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the IL-1 gene cluster resulting in increased IL-1β production have been associated with increased risk for gastric cancer.
|
27460807 |
2016 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis showed a significant correlation between IL-1β-511C/T polymorphism and susceptibility to gastric cancer in residents of southern China and in patients with intestinal-type gastric cancer, but not in residents of northern China or in patients with diffuse gastric cancer.
|
27215350 |
2016 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, H. pylori infection has a synergistic effect on the development of GC with IL-1β gene polymorphisms, and the highest prevalence of severe gastric abnormalities are found in patients with both host and bacterial high-risk genotypes (cagA(+)/vacAs1(+)/IL-1β-511T).
|
27076787 |
2016 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Disruption of the HNF4α/IL-1R1/IL-1β/NF-κB circuit during Hp infection maybe an effective means of preventing the associated GC.
|
26870992 |
2016 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Based on subgroup analysis, H. pylori infection and genotype analysis using PCR-RFLP methods increase the association between IL-1β-511 T allele carrier and risk of stomach cancer.
|
25258120 |
2015 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations.
|
24557417 |
2015 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that SNPs in the IL-1 family genes play important roles in the development of GC and the IL-1F5 might be the target gene of miR-197, and miR-197 might negatively regulate its expression.
|
26632693 |
2015 |
Malignant neoplasm of stomach
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IL-1β stimulated uPA expression through ERK and NF-κB in gastric cancer, which may therefore be promising targets for gastric cancer therapy.
|
24626561 |
2014 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The proinflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors and polymorphisms in the IL-1 gene cluster leading to increased IL-1β production have been associated with increased risk for gastric cancer.
|
25172489 |
2014 |
Malignant neoplasm of stomach
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
IL-1β may be an important mediator for H. pylori induced gene methylation during GC development.
|
24023501 |
2013 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
CTD_human |
Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains.
|
22414649 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results demonstrated that the IL-1β -511 C/C and IL-1β -511 C/T alleles were associated with chronic gastritis in H. pylori-positive patients (P = 0.04 and P = 0.05, respectively) and the IL-1β -511 C/C genotype was associated with GC (P = 0.03).
|
22714811 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moderate to high Cap consumption synergistically increased GC risk in genetically susceptible individuals (IL1B-31C allele carriers) infected with the more virulent H. pylori (CagA+) strains.
|
22414649 |
2012 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the Chinese subgroup, nominally significant associations were shown between (i) EBBR2+1963G (rs1801200) and H. pylori infection (per-allele OR: 0.48, 95% CI 0.23, 0.98, P = 0.04), (ii) PTGS2-1195G (rs689466) and an increased risk of GC on adjusting for H. pylori status (OR: 1.53, 95% CI 0.99, 2.37, P = 0.05), and (iii) IL1B-1473C (rs1143623) and a decreased risk of GC (OR: 0.64, 95% CI 0.41, 0.99, P = 0.05).
|
21649724 |
2011 |
Malignant neoplasm of stomach
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Functionally, 2 RUNX3 isoforms may contribute differentially to intestinal-type gastric cancer susceptibility, at least in part through regulating NF-κB activity and IL1B expression.
|
21523770 |
2011 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
So far, a number of association studies have focused on the effect of polymorphisms in IL-1β and TNF-α genes on the susceptibility to gastric cancer (GC).
|
21246243 |
2011 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the IL1B-511T/T allele is associated with enhanced hypermethylation of multiple CpG island loci, which might contribute to an increase in the risk for gastric cancer in individuals with H. pylori infection and IL1B-511T/T allele.
|
20405297 |
2010 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls.
|
20332462 |
2010 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin 1-beta gene polymorphisms and risk of gastric cancer in Sweden.
|
19031173 |
2009 |
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
CTD_human |
The effects of interleukin-1beta (IL-1beta) and epigenetic mechanisms on 15-PGDH regulation were assessed in gastric cancer cell lines.
|
19584167 |
2009 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians.
|
19861615 |
2009 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC.
|
18807132 |
2008 |
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that interleukin-1beta (IL-1B) genes play a crucial role in the genetic predisposition to gastric cancer although there is no information about their role in different subtypes of gastric cancer.
|
18688641 |
2008 |