Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hesperidin alleviates BLM-induced IPF via inhibition of TGF-β1/Smad3/AMPK and IκBα/NF-κB pathways which in turn ameliorate the modulation of oxido-inflammatory markers (Nrf2 and HO-1) and pro-inflammatory markers (TNF-α, IL-1β, and IL-6) to reduce collagen deposition during pulmonary fibrosis.See also Figure 1(Fig.1).
|
31611754 |
2019 |
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, IkBα-NFkB signaling activation by Hsp27, which resulted in the facilitation of Twist, IL1β, and IL6 expression, is involved in the EMT process that is tightly connected to the development of IR-induced lung fibrosis.
|
31126962 |
2019 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Additionally, GPS significantly decreased the levels of inflammatory cytokines including TNF-α and IL-1β in bronchoalveolar lavage fluid and reduced the content of hydroxyproline in lungs of PF mice.
|
29278701 |
2018 |
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Withaferin A treatment reduced the progression of PF by modulating the EMT related cell markers both <i>in vivo</i> and <i>in vitro.</i> Withaferin A ameliorated the expression of inflammatory cytokines including NF-κB p65, IL-1β and TNF-α, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin.
|
29623041 |
2018 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-1 receptor antagonist-deficient (IL-1Ra-KO) mice were more severely affected by BLM injection, as shown by dermal and pulmonary fibrosis, compared with wild-type (WT) mice.
|
30042768 |
2018 |
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After 21 days of exposure to PM<sub>2.5</sub> through oropharyngeal aspiration, Balb/c mice showed increased IL-1β and TGF-β1 levels in the bronchoalveolar lavage fluid (BALF) of lung and significant collagen deposition around small airways of mice, suggesting potential lung inflammation and pulmonary fibrosis.
|
30092543 |
2018 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Statistical analysis confirms a correlation between IL-1β production in BMDM and the lung fibrosis.
|
28677920 |
2017 |
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We observed significant up-regulation of IL-1β and IL-6 in bronchoalveolar lavage fluid (BALF) in bleomycin-induced lung fibrosis in vivo.
|
23526221 |
2013 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Neutralization of interleukin-1 beta attenuates silica-induced lung inflammation and fibrosis in C57BL/6 mice.
|
23640035 |
2013 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
RGD |
Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine.
|
23132788 |
2012 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
RGD |
Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis.
|
19945540 |
2010 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In particular, nalp3 mediated inflammasome activation of caspase-1 and conversion of pro-IL-1 to IL-1 play a key role in silica-mediated and bleomycin-mediated pulmonary fibrosis.
|
19633559 |
2009 |
Pulmonary Fibrosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Levels of cytokine in bronchoalveolar lavage (BAL) fluid in patients with pulmonary fibrosis due to sulfur mustard gas inhalation.
|
17266442 |
2007 |
Pulmonary Fibrosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta.
|
15677771 |
2005 |