IL6, interleukin 6, 3569

N. diseases: 2367; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn's disease (ANDANTE I and II). 29247068 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE IL-6 levels ranged up to 32.7 ng/mL in active CD (> 5000-fold higher than in controls), but also up to 6.9 ng/mL in inactive CD. 29748708 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE IL-6 was identified as a putative soluble factor responsible in part for changes in VIP expression in CD. 28857361 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE However, serum concentration of IL-6 (119.1 ± 79.6 vs. 52.9 ± 39.1) was higher in Crohn's disease than that in the control. 30584414 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE A high IL-6 concentration on POD 1 is independently associated with the occurrence of postoperative IASCs in patients undergoing elective surgery for CD and could allow for earlier diagnosis and earlier intervention for IASCs compared with C-reactive protein. 29912382 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Furthermore, the monocyte-derived macrophages (MDMs) induced by CD bacteria were more sensitive to E. coli stimulation than the MDMs induced by control bacteria, and demonstrated more M1 characteristics with high IL-6, TNF-α, and IL-12 and low IL-4 production. 29752990 2018
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Ileal CD was associated with IL-6 GC+CC genotypes, identifying C allele as a possible marker of increased risk for ileal CD. 28452812 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE Differences between higher mRNA expression of FoxP3 and IL-6 in inflamed tissue were considered significant in patients with ulcerative colitis (UC) (p=0.011, p=0.000 respectively) and with Crohn's disease (CD) (p=0.008, p=0.000 respectively) in comparison to the normal mucosa of non-IBD persons and we found increased TGFβ1 in CD patients alone (p=0.041). 28088612 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE We propose that an anti-fibrotic miR-29b/IL-6 IL-8/MCL-1L axis may influence intestinal fibrosis in CD. 28190086 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-α G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants. 26316104 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE The interleukin-6 (IL-6) receptor is known to be mainly expressed by hepatocytes, neutrophils, monocytes/macrophages, and some lymphocytes, which have been used as prognostic markers in a variety of inflammatory diseases such as rheumatoid arthritis, asthma, and Crohn's disease. 24668548 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05). 24776844 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE Colonic interleukin (IL)-17+, IL-22, and IL-6 mRNA upregulation and increase in the number of colonic IL-17 cells were demonstrated in both Crohn disease (CD) and ulcerative colitis (UC). 23974060 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE IL-6/STAT3/SOCS3 signaling pathway plays an important role in the pathogenesis of Crohn's disease by induction of the antiapoptotic factors Bcl-2 and Bcl-xl in lamina propria mononuclear cells (LPMCs). 23643741 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE Elevated plasma IL-6 levels were detected in CD (P = 0.004), which strongly correlated with disease activity (ρ = 0.690, P<0.001) but not with IL-6-induced STAT3 phosphorylation. 23950992 2013
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Modifications of cytokine expression between noninflamed and inflamed tissues was characterized by increased IL-17A in UC colon, IFN-γ in CD colon, and IL-17A, IFN-γ and IL-6 in CD ileum. 21994045 2012
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease CTD_human Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation. 21829567 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Patients with Crohn's disease had significantly higher IL-6 than those with ulcerative colitis (UC) and controls. 21877213 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Although no correlation between FPN protein and IL-6 was noted, there was a strong negative correlation between serum iron and IL-6, both in subjects with CD (r=-0.88, P<0.0001) and those without anemia (r=-0.58, P=0.02). 20564534 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE The present study is the first to link the ATG16L1 polymorphism with an excessive production of IL-1β and IL-6 in humans, which may explain the effects of this polymorphism on the inflammatory process in Crohn's disease. 21406388 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE The levels of IL-17A and IL-23 mRNA were significantly higher in UC than in CD while the levels of IL-6 were significantly higher in CD compared with UC. 21945121 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 AlteredExpression disease BEFREE In addition, triptolide (20ng/ml) in vitro was able to down-regulate the IL-6/STAT3 pathway and reduce IL-17 expression in cultured colonic explants from patients with Crohn's disease (CD). 20615550 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Males with IL-6-174GG genotype are prone to develop CD at a younger age than males with the IL-6-174G --> C genotype. 19934771 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 GeneticVariation disease BEFREE Seven SNPs in interleukin 1 (IL1), tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and IL6 genes were analyzed in 116 controls and 99 patients with CD. 19550417 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.400 Biomarker disease BEFREE Interleukine-6 (IL-6) is one of the inflammatory cytokines playing a pivotal role in these conditions, and strategies targeting IL-6 signal show promise in the treatment of chronic inflammatory diseases such as rheumatoid arthritis, juvenile idiopathic arthritis, and Crohn's disease. 18473869 2008