Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3.
|
31801855 |
2020 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Detectable KSHV VL and elevated IL-6 levels are present in a subset of children with KS.
|
30204240 |
2019 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome."
|
30541844 |
2019 |
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model.
|
30265712 |
2018 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08).
|
29381560 |
2018 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF.
|
26675551 |
2016 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.
|
27166260 |
2016 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease.
|
24198402 |
2014 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the viral interleukin-6 homolog from Kaposi sarcoma-associated herpesvirus is also sufficient to induce significant D6 upregulation both in vitro and in vivo, and Kaposi sarcoma and primary effusion lymphoma cells demonstrate high levels of D6 expression.
|
23479571 |
2013 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
|
21984125 |
2011 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.
|
21767154 |
2011 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells.
|
19955303 |
2010 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
|
17483315 |
2007 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6.
|
14672670 |
2004 |
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients.
|
15154666 |
2004 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways.
|
12776188 |
2003 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
|
12176919 |
2002 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several groups have reported that vIL-6 is expressed from the HHV-8 genome at higher levels in PEL and MCD lesions than in KS lesions.
|
12134031 |
2002 |
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
|
12176919 |
2002 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-4, a cytokine with pleiotropic effects, suppresses IL-6 in vivo and modestly inhibits AIDS-KS-derived cells in vitro.
|
12513914 |
2002 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue.
|
11274637 |
2001 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease.
|
11172301 |
2001 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preincubation with recombinant human IL-6 or OSM sensitized KS in a dose dependent manner.
|
11380243 |
2001 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
|
11264189 |
2001 |
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6.
|
10779772 |
2000 |