IL6, interleukin 6, 3569

N. diseases: 2367; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3. 31801855 2020
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Detectable KSHV VL and elevated IL-6 levels are present in a subset of children with KS. 30204240 2019
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome." 30541844 2019
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 GeneticVariation disease BEFREE The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model. 30265712 2018
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08). 29381560 2018
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF. 26675551 2016
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling. 27166260 2016
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease. 24198402 2014
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Expression of the viral interleukin-6 homolog from Kaposi sarcoma-associated herpesvirus is also sufficient to induce significant D6 upregulation both in vitro and in vivo, and Kaposi sarcoma and primary effusion lymphoma cells demonstrate high levels of D6 expression. 23479571 2013
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation. 21984125 2011
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies. 21767154 2011
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells. 19955303 2010
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. 17483315 2007
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6. 14672670 2004
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 GeneticVariation disease BEFREE In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients. 15154666 2004
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways. 12776188 2003
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease LHGDN Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. 12176919 2002
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Several groups have reported that vIL-6 is expressed from the HHV-8 genome at higher levels in PEL and MCD lesions than in KS lesions. 12134031 2002
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 AlteredExpression disease BEFREE Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression. 12176919 2002
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE IL-4, a cytokine with pleiotropic effects, suppresses IL-6 in vivo and modestly inhibits AIDS-KS-derived cells in vitro. 12513914 2002
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue. 11274637 2001
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease. 11172301 2001
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Preincubation with recombinant human IL-6 or OSM sensitized KS in a dose dependent manner. 11380243 2001
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. 11264189 2001
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma
0.400 Biomarker disease BEFREE The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6. 10779772 2000