IL6, interleukin 6, 3569

N. diseases: 2367; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE On this regard, concerns increase when doubts arise regarding the applicability of hyperthermia on NSCLC given the potential interaction of IL-6 with NSCLC. 31807866 2020
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. 30674283 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Moreover, it can be hypothesized that CINC-1 is placed upstream TNF-α, IL-1β, and IL-6 among the prostaglandin-dependent fever-mediator cascade and amidst the prostaglandin-independent synthesis pathway of fever. 30349936 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Greater elevations in IL-1B and IL-6 were observed in patients with pyrexia during the first week of treatment compared to those without pyrexia. 30661097 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Compared to controls, exposure to IL-6 resulted in significant maternal temperature increase [mean temperature difference 0.558°C (95% CI, 0.417-0.698; P < .0001)]. 31094787 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE During mild SI, H<sub>2</sub> reduced plasma surges of proinflammatory cytokines (TNF-α and IL-6) while caused an increase in plasma IL-10 (anti-inflammatory cytokine) and prevented fever. 30261305 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Post-XRT findings included a second wave of fever and increased CRP and IL6, beginning 21 days after CAR T cells, which is late for cytokine-release syndrome from CAR T-cell therapy alone on this trial. 31113804 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE The univariate analysis revealed a statistically significant difference between groups in preoperative fever (p = 0.032), stone burden (p < 0.001), C-reactive protein (p = 0.011), PCT (p < 0.001) and interleukin-6 (p = 0.035) levels. 30747240 2019
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Here, we also found that transcription factor MADS, NFY, HSF, MYB/C and WRKY might play a crucial role in male fertility under the high temperature condition. 31409283 2019
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE Secondary endpoints include the number of occurrences of accompanying symptoms during attacks; the time until a fever attack occurs; the duration of fever attacks; serum C-reactive protein and serum amyloid A; 36-item Short Form Health Survey; general evaluation by a physician (100-mm visual analogue scale); body temperature; the percentage of subjects who achieve FMF 50 at 12 weeks and 24 weeks; and pharmacodynamic assessment, including the measurement of serum TCZ level and soluble IL-6 receptor. 30594222 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE The gilts infected with PRRSV had elevated plasma interleukin-6 levels and developed transient febrile and anorectic responses lasting approximately 21 days. 29539630 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Hyperthermia (42 °C) significantly prevented these changes, i.e., increases in IL-6, α-SMA, and collagen, as induced by TGF-β1 in a time-dependent manner. 29674727 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Vaccination induced systemic inflammation, elevating IL-6 by +419% (p < .001), without fever, sickness symptoms (e.g., nausea, light-headedness), or mood changes (all p's > .21). 29742460 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD (<i>n</i> = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [<i>n</i> = 5], enteroviral meningitis [<i>n</i> = 10], nonspecific viral illness without central nervous system involvement [<i>n</i> = 10]). 29913529 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE High-throughput gene profile analysis identifies nine differentially expressed genes that are closely immune-related upon mild heat, accompanied by IL-6 upregulation, a pyrogenic cytokine usually found during fever. 29938166 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE Univariate analysis revealed a statistically significant difference between postoperative fever and factors, such as sex (p = 0.009), preoperative fever (p < 0.001), stone burden (p < 0.001), pyuria (p = 0.013), urine culture (p < 0.001), and serum levels of C-reactive protein (CRP) (p = 0.003), PCT (p < 0.001), and interleukin-6 (IL-6) (p = 0.003). 29239258 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE PCT, IL-6, and IL-8 in HUCB predicted chorioamnionitis and fever in the delivering mother (89%, 83%, and 72%, respectively). 29563816 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE These findings suggest that the observed rise in IL-6 during hyperthermia is mediated, at least in part, by plasma adrenaline. 30303416 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Both fever and the inflammatory mediators IL-6 and IL-8 were negatively associated with post-transfusion haemoglobin increment. 30159896 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE Patients who reported fever and those with positive culture for Mycobacterium tuberculosis had higher serum levels of IL-6. 30180300 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE INTERLEUKIN-6-PRODUCING PHEOCHROMOCYTOMA AS A NEW REASON FOR FEVER OF UNKNOWN ORIGIN: A RETROSPECTIVE STUDY. 29624096 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE Additionally, fever was associated with elevated IL-6 levels in isolated head injury. 28640776 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Because the patient was under anti-IL-6 therapy at the onset, some symptoms typically seen in DIHS were absent, such as fever and leukocyte count abnormalities. 29569382 2018
CUI: C0015967
Disease: Fever
Fever
0.700 Biomarker phenotype BEFREE Although a majority of patients will achieve a complete response following a single infusion of CD19-targeted CAR-modified T cells (CD19 CAR T cells)<sup>2-4</sup>, the broad applicability of this treatment is hampered by severe cytokine release syndrome (CRS), which is characterized by fever, hypotension and respiratory insufficiency associated with elevated serum cytokines, including interleukin-6 (IL-6)<sup>2,5</sup>. 29808005 2018
CUI: C0015967
Disease: Fever
Fever
0.700 AlteredExpression phenotype BEFREE Collectively, our data showed that activation of NF-κB/IL-6 is involved in moderate hyperthermia treatment induced progression of HCC cells. 29894725 2018