CXCL8, C-X-C motif chemokine ligand 8, 3576

N. diseases: 1254; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Unexpectedly, IL-12, IL-1β and CD163-, but not CD163+, cells induced IL-8 expression in colonic CD4+T cells, which co-expressed IFN-γ and/or IL-17 in UC and not CD. 31206576 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE The DAI scores and the expression levels of IL-6, IL-8 and TNF-α significantly increased in the experimental UC mice compared with the control mice, while the expression levels of IgA and sIgA decreased (all P<0.01). 30783488 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS. 30797423 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE The concentrations of hsCRP, GM-CSF, IFN<i>γ</i>, IL12(p70), and RANTES were higher in UC patients with active than inactive disease whereas those of IL8 and TNF<i>α</i> were significantly lower. 30147719 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE WGCNA Reveals Key Roles of IL8 and MMP-9 in Progression of Involvement Area in Colon of Patients with Ulcerative Colitis. 30074183 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 GeneticVariation disease BEFREE IL-8 antagonist, CXCL8(3-72)K11R/G31P coupled with probiotic exhibit variably enhanced therapeutic potential in ameliorating ulcerative colitis. 29655167 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE We found that levels of inflammatory cytokines TNF-α, IL-1β, IL-6 and IL-8 as well as histological damage in colonic tissues showed that engineered Bifidobacterium effectively reduced dextran sulfate sodium(DSS)-induced ulcerative colitis, we also tested the MPO, verified the above conclusions. 29455070 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Interestingly, a similar pattern of IL-8 expression was also observed in colonic biopsies of ulcerative colitis. 28614208 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Mean IL-8 and human defensin (HD) 5 mRNA levels were similar between HIV and UC participants (p=1.0 and p=0.35, respectively) and were significantly greater in both groups relative to controls (p<0.05 for all). 25768924 2015
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Relative quantitative reverse transcription-polymerase chain reaction was applied to explore the gene expressions of CXCL16, its receptor CXCR6, and interleukin 8, an inflammatory marker, in the colonic biopsies of children with active ulcerative colitis (n=19), children with ulcerative colitis in remission (n=9) and children with no inflammatory condition in colon (n=14). 24630488 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE We then identified potential target genes of the significantly dysregulated miRNAs and genes in active UC vs. controls and found a highly significant inverse correlation between hsa-miR-200c-3p and IL8, an inflammatory marker, and between hsa-miR-200c-3p and CDH11, a gene related to intestinal epithelial barrier function. 25546151 2014
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE In L biopsies from patients with CD, higher expression levels were found for IL-4 (p=0.009) and IL-12p35 (p=0.0005), whereas in L biopsy samples from patients with UC higher expression levels were found for IL-8 (p=0.03), chemokines SCYA3 (p=0.05), SCYA4 (p=0.01) and glutathione S-transferase P1 (p=0.01). 23014361 2013
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Importantly, IL-8 mRNA expression was higher in UC and UCCP patients homozygous for the OCTN1 1672T variant compared to the other genotypes. 21793125 2012
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE In our study, we wanted to examine the correlation between transcript levels of interleukin 8 (CXCL8), interferon gamma inducible protein 10 (CXCL10), myeloid-related protein 14 (calgranulin B), macrophage inflammatory protein 2 alpha (CXCL2) with CAI and EAI in UC. 19203362 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE The expressions of interleukin-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) in the colonic mucosa tissue in mild patients with UC were assayed by immunohistochemistry and RT-PCR. 19083096 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE This study was to investigate the expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-8, and IL-10 mRNAs in the colonic mucosa of patients with ulcerative colitis (UC) during active and quiescent UC. 18942752 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE These results suggest that IL-8 is a novel susceptibility gene to UC in Chinese UC patients, and furthermore, that IL-8 polymorphisms may be related to severe clinical subtype of UC. 19348790 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Furthermore, IL-8 and TNF-alpha expression and nuclear phosphorylated NF-kappaB p65 expression could be immunohistochemically confirmed in inflamed epithelium with cryptitis or crypt abscess in UC patients. 19369513 2009
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE IL-8 response of HT29 cells was greater with Crohn's disease (689 +/- 298 [mean +/- SD] pg IL-8/mL at 4 hours, n = 7) and colon cancer isolates (532 +/- 415 pg/mL, n = 14) than with ulcerative colitis (236 +/- 58 pg/mL, n = 6) or control isolates (236 +/- 100 pg/mL, n = 6, P < 0.0001). 17941093 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease BEFREE Proinflammatory IL-8, degree of histological inflammation, and granulocyte content were similar in UC and CD. 17200145 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE Increased activation of NF-kappaB and high levels of the expression of interleukin (IL)-1beta mRNA and IL-8 mRNA were detected in biopsy specimens from patients with ulcerative colitis. 15955209 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease CTD_human Increased activation of NF-kappaB and high levels of the expression of interleukin (IL)-1beta mRNA and IL-8 mRNA were detected in biopsy specimens from patients with ulcerative colitis. 15955209 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease LHGDN (1) The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with UC, as compared with that in the control specimens (P < 0.05) and had a significant positive correlation with NF-kappaB DNA binding activity (r = 0.8363, P < 0.05; r = 0.6024, P < 0.05, respectively). 12133438 2002
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 AlteredExpression disease BEFREE IL-8 mRNA was significantly higher in inflamed UC samples than in uninflamed samples. 12425554 2002
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.400 Biomarker disease CTD_human (1) The expression of IL-1beta mRNA and IL-8 mRNA was increased significantly in patients with UC, as compared with that in the control specimens (P < 0.05) and had a significant positive correlation with NF-kappaB DNA binding activity (r = 0.8363, P < 0.05; r = 0.6024, P < 0.05, respectively). 12133438 2002