Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 Biomarker disease BEFREE Activation of protease-activated receptor-2 (PAR2) is involved in the mucosal immune pathogenesis of gastroesophageal reflux disease (GERD) that is characterized by proinflammatory cytokines such as interleukin-8 (IL-8). 29672302 2018
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 Biomarker disease BEFREE ATP-induced IL-8 release maybe involved in the pathogenesis of refractory gastroesophageal reflux disease. 27977904 2017
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 AlteredExpression disease BEFREE PAR-2 gene expression was 7- to 10-fold upregulated (P<0.0001) in the mucosa of patients with GERD and correlated positively with IL-8 expression and with histomorphological alterations (dilated intercellular spaces, papillary elongation, basal cell hyperplasia (BCH); P<0.01). 20588261 2010
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 Biomarker disease CTD_human HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes. 20616304 2010
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 Biomarker disease BEFREE To evaluate the expression of the cytokines interleukin-1beta (IL-1beta) and interleukin-8 (IL-8) in the GE mucosa in GERD patients and controls and to correlate the cytokine expression with the histomorphological parameters. 19342859 2009
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 Biomarker disease CTD_human Immune and Inflammatory Responses in GERD and Lansoprazole. 18193101 2007
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 AlteredExpression disease BEFREE The presence of basal zone hyperplasia and intraepithelial neutrophils, histopathological hallmarks of GERD, were associated with higher levels of IL-8 mRNA. 15089887 2004
CUI: C0017168
Disease: Gastroesophageal reflux disease
Gastroesophageal reflux disease
0.360 AlteredExpression disease LHGDN Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease. 14669337 2003