Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that bradykinin-induced IL-8 expression is dependent on B1R which causes phosphorylated STAT3 and acetylated SP-1 to translocate to the nucleus, hence resulting in GBM migration.
|
30366000 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells.
|
31440166 |
2019 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the results suggest that the recurrence of GBM is associated with high gene expression levels VEGFA and CXCL8, and the development of the central nervous system.
|
31788092 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-8 inhibited these effects in GBM-EC co-cultures, while IL-8 supplementation increased CSC-mediated growth and invasion in GBM-monocultures.
|
31227783 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, IL-8 knockdown significantly delayed PDX GBM tumor growth in vivo (p < 0.0005).
|
30926789 |
2019 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified highly upregulated interleukin 8 (IL-8)-CXCR2 axis in tumor cells in high-grade human glioma and AAT-treated orthotopic GBM tumors.
|
30236892 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results highlight a critical pro-angiogenic role of IL-8 in MES GBMs.
|
29644004 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of chemokine IL-8 in glioblastoma progression with particular emphasis on immunomodulation, cellular proliferation, invasion and vascular mimicry.
|
30086759 |
2018 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, IL-8, the main mediator regulating glioblastoma cell invasion, was suppressed in both transcriptional and protein level.
|
29412148 |
2018 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study, the effects of GBP and PGB on SP‑induced activation were investigated in the human glioblastoma astrocytoma U373 MG cell line, which expresses high levels of functional high‑affinity NK1R, and produces interleukin (IL)‑6 and IL‑8 in response to SP.
|
28849160 |
2017 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using constitutively active HRasG12V that mimics enhanced Ras activation, we demonstrate that elevated Ras activity in glioblastoma cells leads to up-regulation of IL-6 and IL-8.
|
26794430 |
2016 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Different types of cyto-chemokines are involved in the crosstalk between hAT-MSCs and BTICs (medulloblastoma and AT/RT: CXCR4/SDF-1, CCR5/RANTES, IL6R/IL-6 and IL8R/IL8; glioblastoma: CXCR4/SDF-1, IL6R/IL-6, IL8R/IL-8 and IGF1R/IGF-1).
|
26076490 |
2015 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that NTS/IL-8/CXCR1/STAT3 signaling is crucial for the maintenance of stem-like traits in GSCs and provides a potential therapeutic target for glioblastoma therapy.
|
25200966 |
2014 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that IL-1β, IL-6, and IL-8 levels and p38 MAPK activity are elevated in human glioblastoma specimens and that p38 MAPK inhibitors attenuate the secretion of pro-inflammatory cytokines by microglia and glioblastoma cells.
|
22528800 |
2012 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that invasiveness of GBM cells is driven at least in part by aberrantly expressed IL-8.
|
20577780 |
2011 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conversely, enforced expression of CypA in the CypA KD cell line, Ud-12, markedly enhanced IL-8 transcripts and restored Ud-12 proliferation, suggesting that CypA-mediated IL-8 production provides a growth advantage to glioblastoma cells.
|
20454998 |
2011 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.
|
20127012 |
2010 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to analyze the methylation status of four critical tumor-associated genes (MGMT, RARbeta, RASSF1A, CDH13), and investigate possible links with inflammatory (interleukin [IL]-6, IL-8) and angiogenic mediators (vascular endothelial growth factor [VEGF], cyclooxygenase [COX]-2) and clinical outcome in 23 glioma samples (6 grade II astrocytomas, 17 grade IV glioblastomas).
|
19809523 |
2010 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma.
|
19668231 |
2009 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness.
|
18524891 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, IL8 is upregulated in PTEN-deficient human glioblastoma tumors.
|
18524891 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We recently reported that bcl-xL regulates interleukin 8 (CXCL8) protein expression and promoter activity in glioblastoma cells.
|
18786178 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We showed that the human glioblastoma cell line U87 secreted considerable levels of IL-8 (CXCL8) upon stimulation by the FPR agonist peptide fMLF.
|
17611713 |
2008 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our results demonstrate the role of NF-kB as the mediator of bcl-xL-induced CXCL8 up-regulation in glioblastoma cells.
|
18786178 |
2008 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines.
|
16356833 |
2006 |