|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the IL-10 gene may confer susceptibility to the development of schizophrenia in the Chinese population.
|
15374585 |
2004 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes.
|
27397081 |
2016 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Previous studies have indicated that genetic variations of IL 10 and DBH are implicated in the positive and negative symptoms in schizophrenia.
|
23951054 |
2013 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We therefore examined the impact of possible correlation between IL-10 genetic variations and the plasma levels of soluble HLA-G (sHLA-G) on schizophrenia risk.
|
27969076 |
2016 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Our results also indicate that the IL-10 gene may play a significant role in the etiology of schizophrenia among Han Chinese.
|
16378687 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms at position -1082, -819 and-592 in the IL-10 promoter region were determined in 171 Turkish patients who were diagnosed with schizophrenia, based on the DSM-IV, and 168 healthy controls, by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).
|
19153889 |
2009 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association of rs4848306 in IL1B gene, rs4251961 in IL1RN gene, rs2228145 and rs4537545 in IL6R with schizophrenia have been observed. rs6676671 in IL10 was associated with early age of onset.
|
26481614 |
2015 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that IL-10 gene polymorphism at position -819 does not confer susceptibility to major depression and schizophrenia, at least in the Korean population.
|
11952921 |
2002 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that IL-10 gene promoter polymorphism is not associated with the development of schizophrenia in the Korean population.
|
12667161 |
2003 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia.
|
17066477 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population.
|
21658228 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating association of single nucleotide polymorphisms (SNPs) and susceptibility of SZ.
|
24603720 |
2014 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Previous studies have indicated that genetic variations of IL 10 and DBH are implicated in the positive and negative symptoms in schizophrenia.
|
23951054 |
2013 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia.
|
21216474 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results also indicate that the IL-10 gene may play a significant role in the etiology of schizophrenia among Han Chinese.
|
16378687 |
2006 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Random-effect meta-analysis showed that increasing maternal CRP (OR = 1.31, 95% CI 1.11-1.55, SMD = 0.15, 95% CI 0.06-0.24, P < 0.01), pro-inflammatory cytokine interleukin (IL)-8 (OR = 1.64, 95% CI 1.06-2.55, SMD = 0.27, 95% CI 0.03-0.52, P = 0.03) and anti-inflammatory cytokine IL-10 (OR = 2.16, 95% CI 1.30-3.59, SMD = 0.43, 95% CI 0.14-0.71, P < 0.01) were significantly associated with schizophrenia in offspring.
|
30212728 |
2018 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In healthy controls, ErbB activation was associated with a marked production of IL-10, which was dampened in schizophrenia.
|
28646138 |
2017 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
LHGDN |
IL-10 gene maps on chromosome 1 (q31-q32), a locus associated with genetic susceptibility to schizophrenia.
|
11922883 |
2002 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Among which, the role of interleukin-10 (IL-10) in SZ has been explored in a number of studies by investigating association of single nucleotide polymorphisms (SNPs) and susceptibility of SZ.
|
24603720 |
2014 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, few studies have linked the role of IL-10 to cognitive deficits in schizophrenia.
|
26971470 |
2016 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.
|
21216474 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data could partly explain the abnormal secretion of IL-10 occurring in schizophrenic patients in response to infections or different stressors and suggest a potential role of IL-10 as a candidate gene for susceptibility to schizophrenia.
|
11922883 |
2002 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population.
|
21658228 |
2011 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has been established that cytokines play a critical role in the regulation of the CNS and recent studies have suggested that dysfunctions of both pro-inflammatory (IL-1beta, IL-6, and TNF-alpha) and anti-inflammatory (IL-1RA and IL-10) cytokines could be involved in the pathophysiology of schizophrenia.
|
14563376 |
2004 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This finding also suggests a relationship between hsCRP, IL-10 and their ratio with aggression in patients with schizophrenia.
|
28174109 |
2017 |