IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE We conclude that the relative overexpression of IL-10 in atopic dermatitis greatest in atopic dermatitis subjects. 7836775 1995
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interestingly, IL-10 mRNA expression by purified T cells of children with allergic and non-allergic asthma and children with atopic dermatitis was strongly decreased as compared with that of healthy controls. 9199877 1997
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Using intracellular cytokine staining and flow cytometry, the cytokine profile [IL-2, IL-4, IL-10, IL-13, and interferon (IFN)-gamma] of both CD4+ and CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients was investigated at the single cell level. 9856820 1998
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Our results demonstrate for the first time that IL-10 receptors may have a role in the pathogenesis of atopic eczema and its upregulation by FK506 and UVA could explain the therapeutic efficacy of these agents. 10563471 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interleukin-10 mRNA expression was significantly enhanced in AD compared with control subjects (P < .05). 10831012 2000
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Using amplification refractory mutation screening PCR, we examined TGFB1 and IL10 gene polymorphisms, which are known to affect cytokine production, in 68 children with moderately severe AD and in 50 nonatopic children. 11496247 2001
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE This study examined the expression of the immunosuppressive cytokines TGF-beta and IL-10, the Th2-type cytokines IL-4 and IL-6, and the Th1-type cytokines IFN-gamma, TNF-alpha, IL-2, IL-12p35 and IL-12p40, in canine atopic dermatitis. 11994107 2002
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Polymorphisms in the genes encoding tumour necrosis factor-alpha (TNFA-238 G/A, -308 G/A), interleukin (IL)-1beta (IL1B-511 T/C, +3953 T/C), IL-6 (IL6-174 C/G), IL-10 (IL10-1082 A/G) and the IL-1 receptor antagonist (IL1RN intron 2) were investigated in German patients with AD (n = 94) and in healthy nonatopic individuals (n = 214) by polymerase chain reaction-based methods and direct cycle sequencing. 12828754 2003
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Having a dog in infancy is associated with higher IL-10 and IL-13 cytokine secretion profiles and reduced allergic sensitization and atopic dermatitis. 14767447 2004
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. 16185274 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Interleukin-10 haplotype associated with total serum IgE in atopic dermatitis patients. 16076299 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE IL-10 promoter polymorphisms are associated with the phenotype of AD in children. 17188628 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis. 17596153 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE SNPs at positions -3575, -2849, -2779, -2763, -1082, -851, -819 and -592 in the IL10 promoter region were genotyped in individuals with atopic dermatitis (n= 47) and nonatopic control subjects (n= 40) using polymerase chain reaction-based techniques and induced heteroduplex generator (IHG) analysis. 19552724 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE FLG mutation, alone and in combination with certain IL-10 or IL-13 polymorphisms, enhances the risk for the development of AD in the Polish population. 21426411 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE After adjusting for multiple tests, the association between IL13 130 and IgE and the interactive effects of IL10-1082 on current rhinitis and IL8 781 on atopic eczema were significant by controlling a false-positive rate of 0.05 and 0.10, respectively. 21749458 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Protective cytokine polymorphisms for AD for seven cytokine genotypes (IL-4 -1098/G:T, TGFbeta cdn25/G:G, IL-4 -33/C:C, IL-1alpha -889/C:C, IFNgamma +874/A:A, IL-10 -1082/A:A, IL-1beta -511/C:C), one cytokine diplotypes, two cytokine haplotypes, and four cytokine alleles were also found. 22427475 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE In our study, genotypes of 7 polymorphisms--LL-4 -1098G/T and -590C/T, IL-6 -174C/G and nt565A/G, and IL-10 -1082A/G, -819C/T, and -592A/C were significantly associated with atopic AD (P < .05). 22533231 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE IL-10 production was significantly decreased in the supernatants from both the HCs and patients with AD after CRH treatment. 22000570 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Mothers who had atopic dermatitis had significantly decreased levels of IL-10 (p = 0.044) in breast milk. 23980846 2013
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis. 23857017 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE To investigate TLR2 and TLR4 expression on PB monocytes during AD exacerbation and to assess the relationships between TLR expressions with AD clinical severity and with serum interleukin (IL) 4, IL-10, and IL-17a levels. 26534745 2016
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Our findings indicate a potential role of IDEC-like in the maintenance of inflammation in atopic dermatitis patients; moreover, IDEC-like may exert a regulatory impact on T cells of AD individuals through IL-10, often induced by agonist mimicking single stranded RNA virus. 28083892 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE The production of IL-6 and IL-10 was impaired by Pam3Cys in supernatants from AD skin. 29672867 2018