IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association. 23633568 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease GWASDB Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. 26654556 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels. 24703990 2014
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups. 29294320 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. 26213801 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS). 29017598 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Rare IL10 coding variants were not detected in BD patients, but we identified 28 known single nucleotide polymorphisms with minor allele frequencies ranging from 0.010 to 0.390, and five novel non-coding variants in five heterozygous cases. ss836185595, located in the IL10 3' untranslated region, was also detected in one Iranian control individual and therefore is not specific to BD. 24708170 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE In IL10, rs1518111 was nominally associated with BD before and after adjustment for population stratification (odds ratio [OR] for T allele 1.20, 95% confidence interval [95% CI] 1.02-1.40, unadjusted P [P(unadj) ] = 2.53 × 10(-2) ; adjusted P [P(adj) ] = 1.43 × 10(-2) ), and rs1554286 demonstrated a trend toward association (P(unadj) = 6.14 × 10(-2) ; P(adj) = 3.21 × 10(-2) ). 22378604 2012
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease GWASCAT Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population. 31721090 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE The present study might suggest that TNF-α -308A/G, IL-10 -1082G/A, -819C/T, -592C/A polymorphisms are associated with BD susceptibility. 24267724 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Polymorphisms in interleukin-10, IL-8 and CD28 genes were also associated with Behçet's disease. 18281862 2008
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese. 27464962 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis. 26068404 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Our study indicates that functional TNF-α, IL10 genotypes or combined TNF-α, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients. 20191386 2010
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Regarding the non-HLA genes, the three SNPs located in IL23R and one of the SNPs in IL10 were found to be significantly associated with susceptibility to BD in our population. 24286189 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). 29895319 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease GWASCAT Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease. 20622878 2010
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease BEFREE These results suggest that TGF-Beta1 and IL-10 gene polymorphisms may affect host susceptibility to BD. 19796538 2010
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.700 GeneticVariation disease GWASDB Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. 20622879 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE In a stratified analysis, a highly significant association between the -1082 AA IL-10 genotype and the steroid dependency was observed in IBD (p < 0.0001), contributing both UC (p = 0.004) and CD (p = 0.003) to this association. 16573780 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.700 GeneticVariation disease BEFREE IL-10 polymorphisms contribute to susceptibility to CD in Spanish population. 16043989 2005