IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1112209
Disease: Abdominal Infection
Abdominal Infection
0.010 AlteredExpression group BEFREE The serum IL-4 and IL-10 levels in pulmonary infection was higher and the serum IL-10 level in pulmonary infection was higher than those in incision infection and abdominal infection (P<0.05). 30675219 2019
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.110 GeneticVariation phenotype BEFREE The data suggest that endogenous T cell-derived opioids might reduce inflammation-induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin-10. 31588671 2020
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.110 Biomarker phenotype HPO
CUI: C0000744
Disease: Abetalipoproteinemia
Abetalipoproteinemia
0.010 AlteredExpression disease BEFREE Levels of ABL, and the serum cytokines, interleukin (IL)-1 β, IL-6, tumor necrosis factor-α (TNF-α) and IL-10 were assessed as were the levels of the oxidants and anti-oxidants, malondialdehyde (MDA), glutathione (GSH) and glutathione peroxidase (GSH-Px), and levels of gingival apoptosis. 28482239 2017
CUI: C1860224
Disease: ABLEPHARON-MACROSTOMIA SYNDROME
ABLEPHARON-MACROSTOMIA SYNDROME
0.010 AlteredExpression disease BEFREE IL10 was downregulated and both IF17F and CCL8 were upregulated in AMS individuals. 28611780 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.010 Biomarker phenotype BEFREE Interleukin-10 (IL10) and it's receptor IL10RA may play an important role for immunological aspects in etiologies of major psychiatric disorders including schizophrenia. 27397081 2016
CUI: C2132198
Disease: Abnormal blistering of the skin
Abnormal blistering of the skin
0.100 Biomarker phenotype HPO
CUI: C0263634
Disease: Abnormal granulation tissue
Abnormal granulation tissue
0.010 Biomarker phenotype BEFREE Here, we investigated the impact of orf virus interleukin-10 and vascular endothelial growth factor-E on the development and resolution of EGT. 29763436 2018
CUI: C4025758
Disease: Abnormal myocardium morphology
Abnormal myocardium morphology
0.100 Biomarker phenotype HPO
Abnormality of blood and blood-forming tissues
0.100 Biomarker disease HPO
CUI: C4021753
Disease: Abnormality of the immune system
Abnormality of the immune system
0.100 Biomarker disease HPO
Abnormality of the periventricular white matter
0.010 GeneticVariation disease BEFREE Interleukin-10 high producer allele and ultrasound-defined periventricular white matter abnormalities in preterm infants: a preliminary study. 16967363 2006
Abnormality of the respiratory system
0.100 Biomarker disease HPO
CUI: C0000833
Disease: Abscess
Abscess
0.010 GeneticVariation phenotype BEFREE Moreover, severe infantile enterocolitis resembling Crohn's disease, caused by loss-of-function mutations in IL-10 and IL-10 receptor, is characterised by a very early onset (usually within the first 3 months of life), unresponsiveness to standard treatment including immunosuppressive therapy, and severe perianal disease with abscesses and fistulas. 25004811 2014
CUI: C0000880
Disease: Acanthamoeba Keratitis
Acanthamoeba Keratitis
0.010 GeneticVariation disease BEFREE IL-22, part of the IL-10 family, and a proinflammatory Th17 cytokine, was detected more often in severe cases than in milder forms of AK (P < 0.02). 28489721 2017
CUI: C1321756
Disease: Achalasia
Achalasia
0.010 GeneticVariation disease BEFREE The GCC haplotype of the IL10 promoter was reported to be associated with a lower risk of achalasia in the discovery sample (odds ratio [OR] = 0.79, 95% confidence interval [CI] = 0.64-0.98, p = 0.029). 21641950 2011
CUI: C0001125
Disease: Acidosis, Lactic
Acidosis, Lactic
0.010 GeneticVariation phenotype LHGDN Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes. 12078789 2002
CUI: C0001125
Disease: Acidosis, Lactic
Acidosis, Lactic
0.010 GeneticVariation phenotype BEFREE Lactic acidosis after cardiac surgery is associated with polymorphisms in tumor necrosis factor and interleukin 10 genes. 12078789 2002
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma
0.010 Biomarker disease BEFREE Serum IL33, sST2, IL-4 and IL-10 concentrations were determined in patients with benign and malignant parotid gland tumors (pleomorphic adenoma, Warthin's tumor, myoepithelioma and acinic cell carcinoma). 29763370 2018
CUI: C0702166
Disease: Acne
Acne
0.110 GeneticVariation disease BEFREE Tumor necrosis factor-α -308 G/A and interleukin 10 -1082 A/G gene polymorphisms in patients with acne vulgaris. 22835835 2012
CUI: C0702166
Disease: Acne
Acne
0.110 Biomarker disease HPO
CUI: C0001144
Disease: Acne Vulgaris
Acne Vulgaris
0.010 GeneticVariation disease BEFREE Tumor necrosis factor-α -308 G/A and interleukin 10 -1082 A/G gene polymorphisms in patients with acne vulgaris. 22835835 2012
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia
0.020 GeneticVariation disease BEFREE Association of IL-4 and IL-10 gene promoter polymorphisms with common variable immunodeficiency. 19249119 2010
CUI: C2936664
Disease: Acquired Hypogammaglobulinemia
Acquired Hypogammaglobulinemia
0.020 Biomarker disease BEFREE B cell differentiation defects in common variable immunodeficiency are ameliorated after stimulation with anti-CD40 antibody and IL-10. 7515919 1994
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.080 Biomarker group BEFREE IL-10 production in AIDS lymphomas was associated with the presence of Epstein-Barr virus (EBV) in lymphomatous cells (p = 0.02). 1330578 1992