IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 AlteredExpression disease BEFREE Furthermore, a positive correlation was observed between IL-10 serum levels and ocular manifestations in BD patients, in contrast to those of IL-17, showing no correlation with the different clinical manifestations. 31122907 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population. 31721090 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Treg and Th17 cell frequencies and Th17 RORγt expression were significantly elevated, and IL-10 concentration in Treg cell supernatants was significantly lower in BD patients than in controls. 30601931 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α. 30907204 2019
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups. 29294320 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 AlteredExpression disease BEFREE We revealed that hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behçet's disease. 29719061 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). 29895319 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS). 29017598 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Rare IL10 coding variants were not detected in BD patients, but we identified 28 known single nucleotide polymorphisms with minor allele frequencies ranging from 0.010 to 0.390, and five novel non-coding variants in five heterozygous cases. ss836185595, located in the IL10 3' untranslated region, was also detected in one Iranian control individual and therefore is not specific to BD. 24708170 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 AlteredExpression disease BEFREE Revealing the key molecular mechanism by which IL-10 expression is regulated is crucial to understanding the pathogenesis of BD. 29096751 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese. 27464962 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution. 26654556 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Behçet's disease (BD) is an immune-mediated and complex disease which has been associated with HLA class I molecules although other genes such as IL23R and IL10 have also been involved in the susceptibility to BD. 26005883 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 AlteredExpression disease BEFREE The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC). 27467286 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. 26213801 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers. 26097239 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 SusceptibilityMutation disease ORPHANET Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis. 26068404 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively). 25940109 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels. 24703990 2014
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE IL10 may be the susceptibility gene for BD in Chinese Han population. 24269690 2014
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Our aim was to fully examine the relationship between IL-10 and BD, the associations between BD and single nucleotide polymorphisms (SNPs) in IL-10-mediated signalling pathways (JAK1, TYK2, and STAT3) were examined in Korean patients with BD. 24428981 2014
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association. 23633568 2013
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013