Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a positive correlation was observed between IL-10 serum levels and ocular manifestations in BD patients, in contrast to those of IL-17, showing no correlation with the different clinical manifestations.
|
31122907 |
2019 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population.
|
31721090 |
2019 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Treg and Th17 cell frequencies and Th17 RORγt expression were significantly elevated, and IL-10 concentration in Treg cell supernatants was significantly lower in BD patients than in controls.
|
30601931 |
2019 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α.
|
30907204 |
2019 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the goal of this study was to measure the correlation of the IL-10 gene polymorphisms with the susceptibility to Behçet's disease compared with the control group in the Azeri population and to determine the expression of this gene in the two groups.
|
29294320 |
2018 |
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We revealed that hypermethylation of promoter region was the principal defect for the IL-10 mRNA low expression in patients with Behçet's disease.
|
29719061 |
2018 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs).
|
29895319 |
2018 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS).
|
29017598 |
2017 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Rare IL10 coding variants were not detected in BD patients, but we identified 28 known single nucleotide polymorphisms with minor allele frequencies ranging from 0.010 to 0.390, and five novel non-coding variants in five heterozygous cases. ss836185595, located in the IL10 3' untranslated region, was also detected in one Iranian control individual and therefore is not specific to BD.
|
24708170 |
2017 |
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Revealing the key molecular mechanism by which IL-10 expression is regulated is crucial to understanding the pathogenesis of BD.
|
29096751 |
2017 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese.
|
27464962 |
2017 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The evaluation of the IL-2 gene polymorphism (p=0.0065) and IL-10 gene polymorphism (p=0.0483) distributions with respect to age of BD onset revealed a statistically significant distribution.
|
26654556 |
2016 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Behçet's disease (BD) is an immune-mediated and complex disease which has been associated with HLA class I molecules although other genes such as IL23R and IL10 have also been involved in the susceptibility to BD.
|
26005883 |
2016 |
Behcet Syndrome
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The same difference was observed in IL-10 levels in culture supernatant after T. Baseline TLR4 expression was significantly higher in BD patients compared to healthy donors (HC).
|
27467286 |
2016 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD.
|
26213801 |
2015 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers.
|
26097239 |
2015 |
Behcet Syndrome
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.
|
26015771 |
2015 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis.
|
26068404 |
2015 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively).
|
25940109 |
2015 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population.
|
26015771 |
2015 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Thus, this study aimed to investigate the associations between IL-6 and IL-10 promoter single-nucleotide polymorphisms (SNPs) and the susceptibility to BD and their implication on plasma levels.
|
24703990 |
2014 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL10 may be the susceptibility gene for BD in Chinese Han population.
|
24269690 |
2014 |
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our aim was to fully examine the relationship between IL-10 and BD, the associations between BD and single nucleotide polymorphisms (SNPs) in IL-10-mediated signalling pathways (JAK1, TYK2, and STAT3) were examined in Korean patients with BD.
|
24428981 |
2014 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the current study of Behçet disease (BD), nonsynonymous variants (NSVs) identified by deep exonic resequencing of 10 genes found by GWAS (IL10, IL23R, CCR1, STAT4, KLRK1, KLRC1, KLRC2, KLRC3, KLRC4, and ERAP1) and 11 genes selected for their role in innate immunity (IL1B, IL1R1, IL1RN, NLRP3, MEFV, TNFRSF1A, PSTPIP1, CASP1, PYCARD, NOD2, and TLR4) were evaluated for BD association.
|
23633568 |
2013 |
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |