Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
BALB/C mice with 2,4,6-Trinitrobenzenesulfonic acid solution (TNBS)-induced colitis, when treated with resveratrol, show improved clinical outcomes and reduce induction of inflammatory T cells (Th17 and Th1) while increasing CD4+Foxp3+ regulatory T cells (Tregs) and IL-10-producing CD4+ T cells. miR microarray analysis and polymerase chain reaction (PCR) validation from CD4+ T cells show treatment with resveratrol decreases the expression of several miRs (miR-31, Let7a, miR-132) that targets cytokines and transcription factors involved in anti-inflammatory T cell responses (Foxp3 and TGF-β).
|
31730734 |
2020 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mice lacking both IL-10 and IL-17A (Il10-/-Il17a-/-) suffered from fatal wasting and manifested more severe colitis compared with Il10-/-Il17a+/- mice.
|
31755523 |
2020 |
Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that altering intestinal iron availability during community assembly modulated the microbiota in non-inflamed wild type (WT) and colitis-susceptible interleukin-10-deficient (<i>Il10<sup>-/-</sup></i>) mice.
|
31179826 |
2020 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
CD4<sup>+</sup> T lymphocytes but not F4/80<sup>+</sup> macrophages isolated from the lamina propria of IL-10-deficient mice with colitis express enkephalin-containing opioid peptides as assessed by cytofluorometry.
|
31588671 |
2020 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TNBS significantly elevated myeloperoxidase (MPO) expression, macroscopic scores, and colon shortening.Oral <i>L. sakei</i> S1 administration resulted in reduction of TNBS-induced loss in body weight, colon shortening, MPO activity, expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB).<i>L. sakei</i> S1 inhibited the expression of inflammatory cytokines IL-1β, IL-6 and TNF-α, induced by TNBS, but enhanced IL-10 expression.<i>L. sakei</i> S1 showed resistance to artificial digestive juices and adherence to intestinal epithelial Caco-2 cells.Thus, <i>L. sakei</i> S1 may inhibit the NF-κB pathway and be used as functional food to treat colitis.
|
31635441 |
2020 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Autophagy induction by rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice.
|
31677991 |
2020 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cobitolimod administration markedly suppressed experimental colitis activity and microarrays analyses demonstrated mucosal IL10 upregulation and suppression of IL17 signaling pathways.
|
31630153 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Exposure to TCC increased dextran sodium sulfate (DSS)- and interleukin 10 (IL-10) knockout-induced colitis, and exaggerated azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice.
|
31760871 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data illustrate that HdAg evokes a unique regulatory program in macrophages, identifies HdAg-evoked IL-10 suppression of macrophage activation, and reveals the ability of HdAg-treated macrophages to educate ( i.e., condition) and mobilize CD4<sup>+</sup>CD25<sup>+</sup> T cells, which could be deployed to treat colonic inflammation.-Reyes, J. L., Lopes, F., Leung, G., Jayme, T. S., Matisz, C. E., Shute, A., Burkhard, R., Carneiro, M., Workentine, M. L., Wang, A., Petri, B., Beck, P. L., Geuking, M. B., McKay, D. M., Macrophages treated with antigen from the tapeworm Hymenolepis diminuta condition CD25<sup>+</sup> T cells to suppress colitis.
|
30668930 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Deletion of IL-6 exacerbates colitis and induces systemic inflammation in IL-10-deficient mice.
|
31679013 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we assessed the role of RHBDF2 in the development of colitis in the context of IL10 deficiency.
|
30694569 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Azoxymethane/Il10 <sup>-/-</sup> Model of Colitis-Associated Cancer (CAC).
|
30798535 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Such an effect triggers colitis in animals deficient in either interleukin-10, a cytokine exerting anti-inflammatory and regulatory functions, or Toll-like receptor 5, a receptor recognizing the bacterial flagellin.
|
31581570 |
2019 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the TNBS model of colitis, Blend 2 reduced the expression of pro-inflammatory genes while increasing the production of anti-inflammatory cytokines, promoting the expansion M2 macrophages and the formation of IL-10-producing Treg cells in the colon's <i>lamina propria</i>.
|
30717413 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Analysis of Il10+/EGFP mice crossed with additional gene-deficient strains and B cell co-transfer studies demonstrated that microbiota-induced IL-10-producing intestinal B cells ameliorated chronic T cell-mediated colitis in a TLR2, MyD88 and PI3K-dependent fashion.
|
31211700 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Many studies have shown that antibiotic therapy can attenuate colitis in IL10-deficient (IL10<sup>-/-</sup>) mice.
|
30974386 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The presence of OG1RF_12399-12402 is not required for <i>E. faecalis</i> colonization of the mouse intestine but is associated with an accelerated onset of experimental colitis in interleukin-10-deficient mice, altered bacterial composition in the colon, enhanced <i>E. faecalis</i> survival within macrophages, and increased proinflammatory cytokine secretion by colon tissue and macrophages.
|
31036600 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-10 (IL10)/interleukin-10 receptor (IL10R) deficiency is a rare disease with life-threatening infantile-onset colitis.
|
30212871 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, we asked whether IVIg-treated macrophages or IVIg could reduce intestinal inflammation in mice during dextran sulfate sodium (DSS)-induced colitis by inducing macrophage IL-10 production in vivo.
|
31054259 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Next, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)-induced colitis mice, and <i>Lactobacillus sakei 07</i> (<i>L07</i>) was identified and selected as probiotic P. In the end, fourteen <i>bifidobacterium</i> strains isolated from stools of healthy males were examined for their antimicrobial activity.
|
30270604 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The TGF-β-induced Tregs that express IL-10 blocked colitis when transferred into the Rag/CD25<sup>-</sup> CD4<sup>+</sup> T cell transfer model of inflammatory bowel disease.
|
30850474 |
2019 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, FOXP3<sup>+</sup> specific conditional knock out mice for MAF did not develop colitis and demonstrated normal levels of IL-10 in their colon, despite the incapacity of regulatory T cells lacking MAF to suppress colon inflammation in Rag1<sup>-/-</sup> mice transferred with naïve CD4<sup>+</sup> T cells.
|
30992496 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the role of PI3Kδ signaling in B cell production of IL-10, following stimulation by resident bacteria and B cell regulatory function against colitis.
|
31546615 |
2019 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This is the first study investigating consequences of hydromorphone in both dextran sodium sulfate (DSS)-induced colitis and spontaneous colitis [IL-10 knockout (IL-10-/-)] mouse model of IBD.
|
31773170 |
2019 |
Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Mutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas.
|
29683948 |
2019 |