Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL-10 knockout (IL-10 KO) mice were used as the human CD models in this study.
|
31677991 |
2020 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohns disease.
|
31158947 |
2020 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease.
|
30776076 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
One of the most common murine models for studying CD is IL-10-/- mouse.
|
31509557 |
2019 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, the levels of IgG x TNF, IgA x IL-10 and IgG x IL-10 were also correlated in CD, indicating that ASCA production may be influenced by the inflammatory response.
|
30884988 |
2019 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, in CD, circRNA_103516 correlated positively with CDAI (<i>P</i> < 0.001), CRP (<i>P</i> < 0.001), ESR (<i>P</i> < 0.001), TNF-α (<i>P</i> < 0.001), and IFN-γ (<i>P</i> < 0.001) and negatively correlated with IL-10 (<i>P</i> = 0.006).
|
31749597 |
2019 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002).
|
30665494 |
2019 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Intracellular IL-10 expression by CD4<sup>+</sup> T-cell subsets in the inflamed guts of patients with IBD (Crohn disease or ulcerative colitis) was compared with that in cells from noninflamed control subjects.
|
29369775 |
2018 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Both CD and UC samples exhibited gene and protein expression of HLA-G; and the HLA-G5 expression is differentially correlated with TNF and IL-10 levels depending on the type of the underlying inflammatory bowel disorder.
|
29588183 |
2018 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We reproduced the association of the interleukin 10 locus with CD (P = .007), although none of the significantly associated variants modified the coding sequence of interleukin 10.
|
29501442 |
2018 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to characterize IL-10R expression and IL-10R-mediated suppression in patients with CD.
|
29045353 |
2018 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Hydrodynamic procedure efficiently delivers the IL10 gene to the human colon, achieving levels of tissue protein expression high enough to mediate pharmacological effects with interest in controlling immune response in patients with Crohn's disease.
|
28708803 |
2017 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Overall, the frequency for carriers of shorter GTn repeats in intron 2 of the TLR2 gene, which have previously been associated with low TLR2 expression and high IL-10 production, was slightly elevated in Crohn's disease and ulcerative colitis compared to healthy controls (16.0% resp.16.7% vs. 12.8%).
|
28388655 |
2017 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study was aimed at figuring out whether DHA could ameliorate the Crohn's colitis by activating GPR120 and whether GPR120 could be a potential therapeutic target for CD.16 week-old mice included in our present study were divided into three groups, WT group, IL-10 KO group and DHA group(IL-10 KO mice with DHA treatment, i.g., 35.5mg/kg/d), containing 8 mice in each group.
|
28039475 |
2017 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
miR-155 Regulates IL-10-Producing CD24<sup>hi</sup>CD27<sup>+</sup> B Cells and Impairs Their Function in Patients with Crohn's Disease.
|
28824639 |
2017 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Interestingly, we also found that B cells presented an inhibitory effect in CD bacteria-mediated skewing toward Th1/Th17 cells and promoted IL-10 secretion in CD bacteria-stimulated PBMCs.
|
29031634 |
2017 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome was upregulated in colonic mucosa of both IL-10-/- mice and Crohn's patients.
|
27993998 |
2017 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent.
|
27558476 |
2016 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease.
|
26090671 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interleukin-10 knockout (IL-10 KO) mouse is a well-established murine model of IBD which develops spontaneous intestinal inflammation that resembles Crohn's disease.
|
25544730 |
2015 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The presence of a family history of IBD and the clinical course of Crohn disease differed between patients with mutations in the IL-10 pathway and those without such mutations.
|
25373860 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, innate cytokine production of TNF-α, IL-1β, IL-6 and IL-10 was not related to historical disease characteristics or disease severity in patients with quiescent CD.
|
26208333 |
2015 |
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), multiple sclerosis (MS), Crohn's disease (CD), and psoriasis.
|
24639111 |
2014 |
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of polymorphisms in the promoter region of the IL-10 gene with the risk of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
|
24407599 |
2014 |