Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE To investigate TLR2 and TLR4 expression on PB monocytes during AD exacerbation and to assess the relationships between TLR expressions with AD clinical severity and with serum interleukin (IL) 4, IL-10, and IL-17a levels. 26534745 2016
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Mothers who had atopic dermatitis had significantly decreased levels of IL-10 (p = 0.044) in breast milk. 23980846 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Association between the IL10 -1082A>G (rs1800896) single-nucleotide polymorphism and atopic dermatitis: a systematic review and meta-analysis. 23857017 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Our data indicate that IL-4alpha and IL-10 polymorphisms may be considered predictive factors of respiratory allergy in children with AD. 22533231 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE CRH-mediated suppression of IL-10 secretion from Treg cells might explain stress-related exacerbations in patients with AD. 22000570 2012
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis. 21426411 2011
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis. 19552724 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis. 17596153 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Association of interleukin-10 gene promoter polymorphism in children with atopic dermatitis. 17188628 2007
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. 16185274 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Interleukin-10 haplotype associated with total serum IgE in atopic dermatitis patients. 16076299 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Having a dog in infancy is associated with higher IL-10 and IL-13 cytokine secretion profiles and reduced allergic sensitization and atopic dermatitis. 14767447 2004
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Polymorphisms in the genes encoding tumour necrosis factor-alpha (TNFA-238 G/A, -308 G/A), interleukin (IL)-1beta (IL1B-511 T/C, +3953 T/C), IL-6 (IL6-174 C/G), IL-10 (IL10-1082 A/G) and the IL-1 receptor antagonist (IL1RN intron 2) were investigated in German patients with AD (n = 94) and in healthy nonatopic individuals (n = 214) by polymerase chain reaction-based methods and direct cycle sequencing. 12828754 2003
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE This study examined the expression of the immunosuppressive cytokines TGF-beta and IL-10, the Th2-type cytokines IL-4 and IL-6, and the Th1-type cytokines IFN-gamma, TNF-alpha, IL-2, IL-12p35 and IL-12p40, in canine atopic dermatitis. 11994107 2003
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Beneficial effects of interleukin-10 therapy and lower endogenous interleukin-10 formation compared with atopic dermatitis and cutaneous T cell lymphomas indicated that interleukin-10 is a key cytokine in psoriasis. 11407990 2001
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 GeneticVariation disease BEFREE Using amplification refractory mutation screening PCR, we examined TGFB1 and IL10 gene polymorphisms, which are known to affect cytokine production, in 68 children with moderately severe AD and in 50 nonatopic children. 11496247 2001
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Increased expression of IL-10 and GM-CSF may be associated with monocyte dysfunction in AD although increase in the expression of GM-CSF mRNA was not statistically significant. 10831012 2000
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 Biomarker disease BEFREE Using intracellular cytokine staining and flow cytometry, the cytokine profile [IL-2, IL-4, IL-10, IL-13, and interferon (IFN)-gamma] of both CD4+ and CD8+ memory/effector T cells circulating in atopic dermatitis (AD) patients was investigated at the single cell level. 9856820 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes. 10563471 1999
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE In skin, pathological overexpression of IL-10 was described om atopic dermatitis. 9550434 1998
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Interestingly, IL-10 mRNA expression by purified T cells of children with allergic and non-allergic asthma and children with atopic dermatitis was strongly decreased as compared with that of healthy controls. 9199877 1997
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic
0.400 AlteredExpression disease BEFREE Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions. 7836775 1995