|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
IL-10 -819CT genotype was associated with advance HIV disease stage (OR = 0.49, P = 0.045).
|
31121270 |
2019 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our findings indicate significant association of pro-inflammatory (IL2, IFN-γ, TNF-α) and anti-inflammatory cytokine gene variants (IL4, IL10) with the risk to acquire the HIV infection and development of AIDS related illness in Indian population.
|
31173933 |
2019 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
IL-10 Promoter -592 Polymorphism may Influence Susceptibility to HIV Infection in South Indian Population.
|
29468971 |
2018 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-10 (IL-10)-producing B cells (B10 cells) may inhibit HIV-specific T cells and are elevated in untreated HIV infection.
|
29271094 |
2018 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Thus, a combination of genetic variations in IFN-γ and IL-10 cytokine genes in a single host associate with HIV disease progression and may help clinicians to better manage the HIV disease if known earlier.
|
26579633 |
2016 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial.
|
25900168 |
2015 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis.
|
23303806 |
2013 |
|
HIV Infections
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The group of patients with liver cirrhosis shows a lower CD4+ T cell count at the inclusion in the study (but not at diagnosis of HIV infection), a higher percentage of individuals with previous alcohol abuse, and a higher proportion of patients with the genotype GG at position -238 of the TNF-α promotor gene; polymorphism at -592 of the IL-10 promotor gene approaches to statistical significance.
|
23840511 |
2013 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin 10 responses are associated with sustained CD4 T-cell counts in treated HIV infection.
|
22693231 |
2012 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Genetic polymorphisms in the IL-10 gene promoter that lead to decreased IL-10 expression have been associated with more rapid disease progression in late stages of HIV infection, suggesting that the anti-inflammatory effects of IL-10 may be protective in the setting of chronic immune activation.
|
20732847 |
2010 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased IL-10 levels have been observed during HIV infection and IL-10 blockade has been shown to enhance T-cell function in some HIV-infected subjects.
|
19365081 |
2009 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Significant elevations of IL-6 and IL-10 were observed in patients having HIV infection.
|
19010320 |
2009 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Similar to what is observed in elderly individuals, low IL-10 production is associated with diabetes in antiviral-treated HIV infection.
|
16437243 |
2006 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Coupled with previous findings, our data suggest that heritable IL4 and IL10 variations may contribute to the acquisition or progression of HIV infection and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations.
|
15021309 |
2004 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity.
|
12468426 |
2003 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The reduction in LPS-induced IL-12 p40 protein and mRNA following acute in vitro HIV infection of THP-1 cells and monocytes was not attributed to IL-10 or TGF-beta activity and was not restored by priming with IL-4, IL-13, or IFN-gamma.
|
12202149 |
2002 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The observation that IL-10 alters NK receptor expression similar to that observed in HIV infection, and the fact that NK receptor expression and activity normalize in parallel with ART-induced reduction of circulating IL-10 levels supports a role for IL-10 in NK cell activity and HIV immunopathogenesis.
|
12045490 |
2002 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
These results indicate that the effects of IL-4 and IL-10 on the CXCR4-SDF-1 receptor-ligand pair may be of particular importance in the cytokine/chemokine environment concerning the inflammatory processes and in the progression of human immunodeficiency virus (HIV) infection.
|
10712670 |
2000 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken.
|
11197608 |
2000 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
Steady-state mRNA ratios of TNF-alpha, IL-4, and IL-10 were significantly increased in patients with highly replicative HIV-infection.
|
10836750 |
2000 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
CTD_human |
Persistent alterations in T-cell repertoire, cytokine and chemokine receptor gene expression after 1 year of highly active antiretroviral therapy.
|
10202824 |
1999 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Therefore, we analysed the regulation of B7 expression by cytokines, namely IL-10 and tumour necrosis factor-alpha (TNF-alpha), the production of which is enhanced in HIV infection and have similar inhibitory effects on B7 expression.
|
10403920 |
1999 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Interleukin 10 increases CCR5 expression and HIV infection in human monocytes.
|
9449724 |
1998 |
|
HIV Infections
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Gamma interferon and interleukin-10 (IL-10) mRNA expression in tuberculosis patients with or without human immunodeficiency virus infection was high, whereas IL-4 expression in the same patients was low.
|
8606100 |
1996 |
|
HIV Infections
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations, together with the observed hyperproduction of IL-10 in HIV-positive patients, may explain the dysregulation of IL-12 production seen in HIV disease.
|
8656012 |
1996 |