|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two IL-10 single nucleotide polymorphisms (rs1800871 and rs1800896) were detected in 120 patients with IBS-D and 144 healthy controls (HC) using SNaPshot.
|
31205078 |
2019 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IBD in infants and children under 2 years of age is life-threatening when patients with IL-10R mutations do not receive allogeneic HSCT.
|
30900524 |
2019 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study.
|
31615448 |
2019 |
|
Irritable Bowel Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
When comparing IBS subtypes, TNFα and IL-17 were significantly (P<0.05) higher, and IL-10 was significantly (P<0.05) lower in diarrhea predominant IBS (IBS-D) compared to HCs, whereas the inflammatory cytokine profile of other subtypes more closely resembled that of HCs.
|
28506572 |
2017 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
The diverse roles of IL-10 in IBS are reviewed here.
|
28237672 |
2017 |
|
Irritable Bowel Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; pc = 0.341 and <i>p</i> = 0.009 and pc = -0.299 and <i>p</i> = 0.023, respectively.
|
29201045 |
2017 |
|
Irritable Bowel Syndrome
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mucosal mRNA expression of IL-10 and FOXP3 tended to be decreased in IBS patients.
|
27272011 |
2016 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Stimulation with Eubacterium limosum resulted in a significantly decreased IL-10 release in HC compared to PI-IBS patients (p < 0.05) and a tendency to decreased IL-13 release in HC compared to PI-IBS patients (p = 0.07).
|
26366730 |
2015 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios (OR) with 95% confidence interval (CI).
|
24409078 |
2013 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
in this group of volunteers in Mexico, the frequency of the IL-10 (-1082G/A) and TNF-alpha (-308G/A) genotypes was similar in IBS and controls.
|
24206549 |
2013 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The IL10-819 CC is a candidate genotype for both IBS and UC in Japanese.
|
23595519 |
2013 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
An association of certain polymorphisms of IL-8 and IL-10 in IBS patients compared to controls was demonstrated, suggesting a role of these cytokine SNPs in the pathophysiology of IBS.
|
22740130 |
2012 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
High producer IL-10 (-1082 G/G; OR: 0.64 [95% CI: 0.48-0.87]) was significantly associated with a decreased risk of IBS.
|
22897390 |
2012 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that some IL-8 and IL-10 SNPs could change individual susceptibility increasing the relative risk in the development of IBS in Blastocystis carriers.
|
22287022 |
2012 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Production of IL10 in response to bacterial motifs was normal in all IBD patients.
|
21519361 |
2011 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multifactor dimensionality reduction analysis revealed that there were no significant interactions of GNB3, IL-10, and TNF-alpha gene variants with susceptibility to IBS (P > 0.05).
|
20337945 |
2010 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS.
|
20177758 |
2010 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association studies with IBS symptom phenotype have generally provided inconsistent results for many candidate genes investigated, such as SLC6A4, GNB3, and IL-10.
|
19655247 |
2009 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Possession of a high producer TNF-alpha and a low producer IL-10 genotype were significantly more prevalent in IBS (9%) versus controls (3%, p= 0.035; OR 3.11, 95% CI 1.03-9.36) and in diarrhea (20%) compared to other IBS subtypes (<4%, p= 0.026).
|
16279907 |
2005 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 polymorphisms in Spanish patients with IBD.
|
16043989 |
2005 |
|
Irritable Bowel Syndrome
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients with irritable bowel syndrome had significantly reduced frequencies of the high producer genotype for interleukin 10 than controls (21% v 32%; p=0.003).
|
12477767 |
2003 |
|
Irritable Bowel Syndrome
|
0.400 |
Biomarker
|
disease |
CTD_human |
Rapid development of colitis in NSAID-treated IL-10-deficient mice.
|
12404228 |
2002 |