IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 AlteredExpression disease BEFREE NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD. 28944953 2018
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE Conversely, IL-6 and IL-10 were greater in aGVHD group, especially after curdlan stimulation (P = .005 and P = .012). 28263922 2017
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE A significant association was found between aGvHD grades II-IV and SNPs of donor IL10-1082GG, and Fas-670CC + CT and recipient IL18-607 TT + TG genotype. aGvHD grades III-IV resulted associated with donor IL10-1082GG, Fas-670CC + CT, and TLR4-3612TT as well as the use of peripheral CD34+ cells as stem cell source. 25973432 2015
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Furthermore, patients who received grafts from donors with an IL-10 -819 CC genotype experienced more frequent grade I-IV aGVHD (OR, 2.306 (95% CI, 1.168-4.551)). 25116082 2015
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Also there were negative association between recipient IL-10/CAA haplotype and donor IL-4Ra/A allele and development of aGVHD. 23645090 2013
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE It is unclear whether IL-10 promoter polymorphism is associated with the occurrence of aGvHD in allogeneic HSCT. 23690289 2013
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Functional IL-10 polymorphism associated features influenced the risk of aGvHD with a positive effect of ACC on the pool of Treg in blood. 24498995 2013
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE IL-10 is made by a variety of donor and host cells, but the functional relevance of its source and its role in the biology of acute GVHD are not well understood. 22262800 2012
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE In multivariate analysis, recipients without the A-T-A IL-10 haplotype had a higher risk of aGVHD (relative risk [RR] = 0.764; 95% confidence interval [CI]: 0.460-1.269; P = .096) and grades II-IV aGVHD (RR = 0.413; 95% CI: 0.245-0.697; P = .001). 20457266 2011
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE These results suggest that pediatric patients possessing the IL-10 GCC haplotype may be protected from the occurrence of severe aGVHD in the setting of matched sibling HSCT. 21358669 2011
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 AlteredExpression disease BEFREE In contrast, IL-10 levels in the blood were associated with the occurrence of aGVHD. 20195716 2010
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE The difference in genotypic IL-10 production between patient and donor in combination with patient IL-10Rbeta A/A genotype predisposed strongly to acute GvHD (OR = 7.15, p = 0.000023). 19409109 2009
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Although genetic variation in IL10 pathway affects risk of acute GVHD and non-relapse mortality in HLA-identical sibling transplants, the current results indicate that genetic variation in the IL10 pathway does not significant affect these outcomes in unrelated donor transplants suggesting that the strength of the alloimmune response in the latter exceeds the anti-inflammatory activity of IL10. 19295315 2009
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE We observed positive correlations between a lower risk of clinically significant aGvHD and both the presence of -1082G -819C -592C IL-10 haplotype when both R and D are considered together and the absence of R IL-1RA allele 2. 16984283 2006
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 AlteredExpression disease BEFREE In conclusion, a high IL-10 gene expression in the recipient MNCs may be related to a reduced incidence of acute GVHD grades II to IV and a reduced graft-versus-tumor effect after HCT with nonmyeloablative conditioning. 16399568 2006
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE These data suggest an interaction of the patient IL-10/-592 and donor IL10RB/c238 genotypes on risk of GVHD, further supporting the hypothesis that the IL-10 pathway plays an important role in controlling the severity of acute GVHD. 16109775 2005
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE In this study, reverse transcription-polymerase chain reaction (RT-PCR) was used to explore the mRNA expression of interleukin (IL)-2, interferon (IFN)-gamma, IL-4, IL-10 and IL-12 in the PBMC of allo-PBSCT patients with aGVHD and in controls. 15852028 2005
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE These analyses confirmed the independent contribution of recipient IL-10 GCC/GCC (odds ratio = 0.085, p = 0.046) and donor IL-6 GG (odds ratio = 3.934, p = 0.034) genotypes to the risk of aGVHD. 15993715 2005
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE IL-10 plays a negative role in the development of aGVHD and graft rejection. 12875717 2003
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE Treatment of primary human and murine T cells with TIP in vitro resulted in the secretion of IFN-gamma, TNF-alpha, and IL-10, whereas in vivo TIP had a protective effect in a mouse acute graft-versus-host disease (GVHD) model. 12598909 2003
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Analysis of all 993 transplant recipients showed that, as compared with the C/C genotype, the IL10 -592A/A genotype was associated with a decreased risk of grade III or IV acute GVHD (hazard ratio, 0.4; 95 percent confidence interval, 0.2 to 0.9; P=0.02) and death in remission (hazard ratio, 0.6; 95 percent confidence interval, 0.3 to 1.0; P=0.05). 14657427 2003
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 Biomarker disease BEFREE Interestingly, we also found that (1) time to neutrophil recovery was shorter when donors were FcgammaRIIIb HNA-1a/HNA-1b (HR = 1.77; P =.002); (2) donor IL-1Ra (absence of IL-1RN*2) increased the risk for acute graft-versus-host disease (GVHD) (II-IV) (HR = 2.17; P =.017); and (3) recipient IL-10 (GG) and IL-1Ra genotypes increased the risk for chronic GVHD (P =.03 and P =.03, respectively). 12393699 2002
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Logistic regression analysis demonstrated that patient VDR genotype, along with previously identified IL-10(-1064) and IFN-gamma genotype to be risk factors for severe acute GVHD. 12203138 2002
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE In contrast to HLA-identical sibling bone marrow transplantation, in mismatched unrelated CBT, neither the cytokine genotypes TNFd3/d3 alone or in combination with IL-10(-1064) alleles nor the minor histocompatibility antigens HY, HA-1, and CD31 exon 125 were associated with aGvHD grades II to IV. 12438965 2002
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.100 GeneticVariation disease BEFREE Logistic regression analysis confirmed the association of severe aGVHD with recipient genotype at IFNgammaIntron1 (odds ratio [OR] 3.92; P =.02), IL-10(-1064) (OR 4.61; P =.026) and TNFd (OR 3.29; P =.039), and that of cGVHD with recipient IL-6(-174) genotype (OR 4.25; P =.007), in addition to age, gender mismatch, and underlying disease. 11520812 2001