Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE IL10 low-frequency variants in Behçet's disease patients. 24708170 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Behçet's disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R-IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide association study (GWAS). 29017598 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Interleukin-4 and Interleukin-10 Gene Polymorphisms in Patients with Inflammatory Bowel Disease. 28872970 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Monogenic defects in the interleukin-10 (IL-10) pathway are extremely rare and cause infantile-onset inflammatory bowel disease (IBD)-like pathology. 28644354 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey. 28267044 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Interleukin-10 receptor mutation presenting with severe nappy ulceration and infantile inflammatory bowel disease. 28597964 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker group BEFREE IL10 receptor (IL10R) deficiency causes severe infantile-onset inflammatory bowel disease. 29023267 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker group BEFREE To study the genetic association and epistatic interaction of the interleukin (IL)-10 and IL-10/STAT3 pathways in pediatric inflammatory bowel disease (IBD). 28785144 2018
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inflammatory bowel disease. 28770550 2018
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype. 26654556 2017
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker group BEFREE Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2-like protein 12 in patients with inflammatory bowel disease. 28120341 2017
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker group CTD_human Genetic and candidate gene analyses in an Il10-deficient IBD mouse model system identified Cd14 as a potentially protective candidate gene. 28411859 2017
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers. 26097239 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Interleukin-10 gene polymorphisms are associated with Behcet's disease but not with Vogt-Koyanagi-Harada syndrome in the Chinese Han population. 26015771 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Behçet's disease (BD) is an immune-mediated and complex disease which has been associated with HLA class I molecules although other genes such as IL23R and IL10 have also been involved in the susceptibility to BD. 26005883 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE This meta-analysis showed that IL-10 polymorphisms are associated with vasculitis susceptibility, especially in WG and BD. 26213801 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation disease BEFREE Non-HLA genetic associations such as endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R) and IL10 variations suggest that BD shares susceptibility genes and inflammatory pathways with spondyloarthritis. 26068404 2016
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2016
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease. 25373860 2016
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE Although deleterious mutations in interleukin-10 and its receptor molecules cause severe infantile-onset inflammatory bowel disease, there are no reports of mutations affecting this signaling pathway in Japanese patients. 26822028 2016
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker group BEFREE Through plasma-induced signature analysis, we have defined a unique, partially TGF-β/IL-10-dependent immunoregulatory signature associated with IBD that may prove useful in predicting therapeutic responsiveness. 26660358 2016
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE On the genetics of the Silk Route: association analysis of HLA, IL10, and IL23R-IL12RB2 regions with Behçet's disease in an Iranian population. 25940109 2015
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker disease BEFREE Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease. 24703990 2015
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE The associations in IL10 and IL18R1 are shared with inflammatory bowel disease, suggesting common etiologic pathways. 25200001 2015
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation group BEFREE The nucleotide-binding oligomerization domain containing-2 gene, commonly involved in multifactorial risk of Crohn's disease, and interleukin 10 receptor genes, associated with rare forms of early onset inflammatory bowel diseases, were sequenced in an early onset patient. 24595243 2015