|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder.
|
16787706 |
2006 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
An association study was performed between the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), the inositol polyphosphate 1-phosphatase gene (INPP1) and bipolar disorder using our sample of proband/parent trios.
|
11901356 |
2002 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.
|
11901356 |
2002 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Two enzymes involved in the phospholipase C signalling system, namely the myo-inositol monophosphatase (IMPase) and the inositol polyphosphate 1-phosphatase (IPPase), have been postulated as targets for the therapeutic action of lithium in manic-depressive illness.
|
10780272 |
1999 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
BEFREE |
Two enzymes involved in the phospholipase C signalling system, namely the myo-inositol monophosphatase (IMPase) and the inositol polyphosphate 1-phosphatase (IPPase), have been postulated as targets for the therapeutic action of lithium in manic-depressive illness.
|
10780272 |
1999 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Future studies are therefore need to determine whether allelic variants of the INPP1 gene are associated with a favourable efficacy of lithium in manic-depressive illness.
|
9682271 |
1998 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Future studies are therefore need to determine whether allelic variants of the INPP1 gene are associated with a favourable efficacy of lithium in manic-depressive illness.
|
9682271 |
1998 |
|
Autistic Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism.
|
14627686 |
2003 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.
|
11901356 |
2002 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.030 |
Biomarker
|
disease |
BEFREE |
Two enzymes involved in the phospholipase C signalling system, namely the myo-inositol monophosphatase (IMPase) and the inositol polyphosphate 1-phosphatase (IPPase), have been postulated as targets for the therapeutic action of lithium in manic-depressive illness.
|
10780272 |
1999 |
|
MAJOR AFFECTIVE DISORDER 2
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Future studies are therefore need to determine whether allelic variants of the INPP1 gene are associated with a favourable efficacy of lithium in manic-depressive illness.
|
9682271 |
1998 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity.
|
24738946 |
2014 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Inactivation of INPP1 leads to a reduction in glycolytic intermediates that feed into the synthesis of the oncogenic signaling lipid lysophosphatidic acid (LPA), which in turn impairs LPA signaling and further attenuates glycolytic metabolism in a feed-forward mechanism to impair cancer cell motility, invasiveness, and tumorigenicity.
|
24738946 |
2014 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This is the first study to report the upregulation of the INPP1 gene in a human cancer and should facilitate further studies looking at the role of phosphatidylinositol signaling reactions in human colorectal cancer.
|
10747296 |
2000 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This is the first study to report the upregulation of the INPP1 gene in a human cancer and should facilitate further studies looking at the role of phosphatidylinositol signaling reactions in human colorectal cancer.
|
10747296 |
2000 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
INPP1 up-regulation by miR-27a contributes to the growth, migration and invasion of human cervical cancer.
|
31557403 |
2019 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We show here that inositol polyphosphate phosphatase 1 (INPP1) is highly expressed in aggressive human cancer cells and primary high-grade human tumors.
|
24738946 |
2014 |
|
Suicidal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.
|
23453640 |
2013 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to report the upregulation of the INPP1 gene in a human cancer and should facilitate further studies looking at the role of phosphatidylinositol signaling reactions in human colorectal cancer.
|
10747296 |
2000 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to report the upregulation of the INPP1 gene in a human cancer and should facilitate further studies looking at the role of phosphatidylinositol signaling reactions in human colorectal cancer.
|
10747296 |
2000 |