Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
INS mutations have a broad spectrum of clinical presentations, ranging from severe neonatal onset to mild adult onset, which suggests that the products of different mutant INS alleles behave differently and utilize distinct mechanisms to induce diabetes.
|
29890547 |
2020 |
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
This case could help us understand the role of the INS mutation in the development of diabetes.
|
30915639 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Together, the results demonstrate that the INS-PLLA PMs have a strong potential as an effective strategy for inhalation treatment of diabetes.
|
30284409 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Furthermore, it reveals that even subtle changes in proinsulin protect NOD mice from diabetes.
|
31821343 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
ERAD deficiency may contribute to the development of diabetes by affecting proinsulin processing in the ER, intracellular Ca<sup>2+</sup> concentration, and mitochondrial function.
|
30626610 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
C-peptide and proinsulin were measured in fasting and stimulated sera from 319 subjects with long-standing type 1 diabetes (≥3 years) and 12 control subjects without diabetes.
|
30530850 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
In genetically obese mice with otherwise wild-type islets, disulfide-linked complexes of proinsulin are more abundant, and leptin receptor-deficient mice, the further increase of such complexes tracks with the onset of islet insulin deficiency and diabetes.
|
31184302 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Male Wistar rats were treated with or without streptozotocin (STZ, an insulinopenic model of diabetes) and either α-lipoic (90 mg/kg ip.), α-tocopherol (200 mg/kg po.) or with STZ and supplemented with insulin (STZ + INS: 2.5U/day) for 4 weeks.
|
30242601 |
2019 |
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
It was hypothesized that the INS gene region provides a common genetic causality for diabetes in Samoyeds and Australian Terriers.
|
31587057 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Proinsulin processing is quite sensitive to nutrient flux, and β-cell-specific deletion of the nutrient-sensing protein modifier OGlcNAc transferase (βOGTKO) causes β-cell failure and diabetes, including early development of hyperproinsulinemia.
|
31300553 |
2019 |
Diabetes Mellitus
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Importantly, when replacing IAA with oxPTM-INS-Ab, diabetes risk increased to 100% in children with oxPTM-INS-Ab<sup>+</sup> in combination with GADA<sup>+</sup> and IA-2A<sup>+</sup> , compared with 84.37% in those with IAA<sup>+</sup> , GADA<sup>+</sup> , and IA-2A<sup>+</sup> (P = 0.04).
|
30693639 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Given the fact that proinsulin misfolding plays an important role in diabetes, this study suggests that enhancing ER export may be a potential therapeutic target to prevent/delay β-cell failure caused by proinsulin misfolding and ER stress.
|
31158417 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
The combination of Tregitope-albumin fusions and PPI peptides reduced the incidence of severe diabetes and reversed mild diabetes, over 49 days of treatment and observation.
|
31695065 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
The exercise in sole (EX) and simultaneous forms with INS (DM + INS + EX group) ameliorated the DM-suppressed spermatogenesis and spermiogenesis indices, up-regulated the serum testosterone and insulin levels, enhanced testicular SOD content, inhibited the apoptosis and improved almost all sperm parameters.
|
31642094 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Regulated proinsulin biosynthesis, disulfide bond formation and ER redox homeostasis are essential to prevent Type two diabetes.
|
31184304 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Elevated plasma proinsulin is a sign of β-cell dysfunction in patients with diabetes/prediabetes.
|
31074785 |
2019 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We show that CE prevent insulin-deficient diabetes in male and in female Akita mice using a model of misfolded proinsulin.
|
29972779 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We have previously shown that the introduction of furin-cleavable human insulin (INS-FUR) to the livers in several animal models of diabetes resulted in the reversal of diabetes and partial pancreatic transdifferentiation of liver cells.
|
29578255 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Proinsulin misfolding is a phenotype that is very much linked to deficient insulin production and diabetes, as is seen in a variety of contexts: rodent models bearing proinsulin-misfolding mutants, human patients with Mutant INS-gene-induced Diabetes of Youth (MIDY), animal models and human patients bearing mutations in critical ER resident proteins, and, quite possibly, in more common variety type 2 diabetes.
|
30230185 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
One hundred rats were divided into five groups: DM+PLAC, DM+CURC, DM+INS, DM+CURC+INS, and non-DM (CURC, curcumin; PLAC, placebo; INS, insulin).
|
29857981 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
They allow the characterization of preproinsulin epitopes recognized by CD8<sup>+</sup> and CD4<sup>+</sup> T cells upon immunization against human preproinsulin or during diabetes development.
|
29967002 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
We previously reported the development of an oral vaccine for diabetes based on live attenuated Salmonella-expressing preproinsulin (PPI) as the autoantigen.
|
30416020 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.
|
29377149 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Herein, we critically review the literature on the effects of proinsulin misfolding and ER stress on β-cell dysfunction and loss in diabetes with emphasis on β-cell dynamics, and discuss the gaps in understanding the role of proinsulin misfolding in the pathophysiology of diabetes.
|
30230182 |
2018 |
Diabetes Mellitus
|
0.700 |
Biomarker
|
group |
BEFREE |
Moreover, proAVP misfolding in hereditary central diabetes insipidus likely shares common physiopathological mechanisms with proinsulin misfolding in hereditary diabetes mellitus of youth.
|
28920918 |
2017 |