Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Proinsulin is sensitive to reflect glucose intolerance.
|
31222973 |
2020 |
Impaired glucose tolerance
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In 52 obese children selected for elevated proinsulin levels and/or impaired glucose tolerance, we found eight known variants and two novel heterozygous variants (c.1095 + 1G > A and p.S24C) by sequencing the <i>PCSK1</i> gene.
|
28271036 |
2017 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Individuals with impaired glucose tolerance have increased proinsulin levels, despite normal glucose or C-peptide levels.
|
21779873 |
2011 |
Impaired glucose tolerance
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In animal models for type 2 diabetes the contents of preproinsulin mRNA are lowered, which might suggest that an impaired metabolism of preproinsulin mRNA contributes to the development of glucose intolerance and diabetes.
|
18621093 |
2009 |
Impaired glucose tolerance
|
0.400 |
AlteredExpression
|
phenotype |
LHGDN |
Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice.
|
17127405 |
2007 |
Impaired glucose tolerance
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Defective proinsulin processing leads to glucose intolerance, but neither insulin resistance nor diabetes develop despite obesity.
|
16644867 |
2006 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In adults with impaired glucose tolerance (IGT) and obesity (OB), an elevated proinsulin (PI) is predictive of type 2 diabetes mellitus (DM) and precedes the diagnosis by 5-20 yr.
|
12364457 |
2002 |
Impaired glucose tolerance
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Oral glucose tolerance tests on subjects with the presenilin 2 Met239Val mutation unaffected by early onset familial Alzheimer's disease (mean age 35 years) and on their first-degree relatives without the mutation demonstrated no evidence of glucose intolerance or increased proinsulin secretion.
|
10362543 |
1999 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
At 120' both insulin and proinsulin values increased from NGT to IGT, but with development of diabetes a reduction was seen in the responses.
|
9768375 |
1998 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We determined GAD and islet cell (ICA512) autoantibodies from 215 NIDDM individuals and from 14 individuals with impaired glucose tolerance (IGT) of 68 families, including 1 family with maturity-onset diabetes of the young (MODY) and 3 families ascertained specifically for a mixture of NIDDM and IDDM.
|
9250448 |
1997 |
Impaired glucose tolerance
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Both fasting and post-glucose levels of proinsulin were elevated in patients with diabetes, but not in the relatives with IGT or NGT.
|
7821172 |
1994 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The development of a mild form of IDDM may be expected in cases with pre-existing IGT for more than one year.
|
2022175 |
1991 |
Impaired glucose tolerance
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
Based on the recent demonstration of elevated serum proinsulin levels in cystic fibrosis patients with impaired glucose tolerance, it was hypothesized that proinsulin could be an indicator of altered beta-cell function.
|
2792577 |
1989 |
Impaired glucose tolerance
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Recent epidemiologic studies of the determinants and natural history of IDDM using HLA typing and detecting islet cell antibodies have shown that HLA-identical siblings of probands with IDDM are at extremely high risk of developing IDDM, and that islet cell antibodies and glucose intolerance usually appear long before clinical manifestations.
|
3902426 |
1985 |