|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
Methods Mutation analysis of MODY genes (GCK, HNF1A, HNF4A, HNF1B, ABCC8, INS and KCNJ11) was performed using targeted NGS in 106 patients with a clinical diagnosis of MODY.
|
30447144 |
2018 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we identified a causative mutation in INS responsible for maturity-onset diabetes of the young 10 (MODY10) in a Chinese population and demonstrated that this mutation affected β cell function by inducing ER stress.
|
28992123 |
2017 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Another monogenic diabetes gene, the preproinsulin gene (INS), is unique in that INS mutations can cause hyperinsulinemia, hyperproinsulinemia, neonatal diabetes mellitus, one type of maturity-onset diabetes of the young (MODY10), and autoantibody-negative T1D.
|
27035557 |
2016 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the insulin (INS) gene rarely occur in patients with MODY.
|
27659712 |
2016 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the insulin (INS) gene rarely occur in patients with Maturity-Onset Diabetes of the Young (MODY).
|
25721872 |
2015 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
This may also have a negative effect on the WT proinsulin simultaneously biosynthesized in β-cells and therefore play a major role in the development of MODY in patients producing [GlnB22]-insulin.
|
25423173 |
2014 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GermlineCausalMutation
|
disease |
ORPHANET |
The lessons of early-onset monogenic diabetes for the understanding of diabetes pathogenesis.
|
22498247 |
2012 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Mutations in NEUROD1, PDX1 (IPF1), CEL and INS are rare causes of MODY.
|
21521318 |
2011 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
The INS gene was sequenced in 16 French probands with unexplained MODY, 95 patients with nonautoimmune early-onset diabetes (diagnosed at <35 years) and 292 normoglycemic control subjects of French origin.
|
20007936 |
2010 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
The most frequent genes involved in monogenic diabetes [KCNJ11 and INS for neonatal diabetes and HNF1A and HNF4A for maturity-onset diabetes of the young (MODY)] were directly sequenced.
|
19900242 |
2009 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
The INS gene was sequenced in 285 patients with diabetes diagnosed before 2 years of age, 296 probands with maturity-onset diabetes of the young (MODY), and 463 patients with young-onset type 2 diabetes (nonobese, diagnosed <45 years).
|
18162506 |
2008 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.
|
17334640 |
2007 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.
|
16604193 |
2006 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
The Ins2Akita mouse as a model of early retinal complications in diabetes.
|
15914643 |
2005 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.
|
11981430 |
2002 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
Fasting proinsulin and the proinsulin/insulin ratio were similar in MODY members of kindred LZ and subjects from control group 1, but were significantly lower than in MODY members of kindred SA (P < 0.02 and P < 0.01, for proinsulin and proinsulin/insulin ratio, respectively).
|
10347805 |
1999 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.
|
9593767 |
1998 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
MGD |
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice.
|
9133560 |
1997 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
BEFREE |
We determined GAD and islet cell (ICA512) autoantibodies from 215 NIDDM individuals and from 14 individuals with impaired glucose tolerance (IGT) of 68 families, including 1 family with maturity-onset diabetes of the young (MODY) and 3 families ascertained specifically for a mixture of NIDDM and IDDM.
|
9250448 |
1997 |
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Maturity onset diabetes mellitus in young
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|