|
Complications of Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Patients with mutations of the insulin receptor gene (INSR) have extreme insulin resistance and are at risk for early morbidity and mortality from diabetes complications.
|
31588494 |
2020 |
|
Dengue Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, siRNA-mediated knockdown and treatment with a small-molecule inhibitor of the insulin receptor kinase concur to assign a crucial role for this enzyme in the replication of dengue and Zika viruses in cultured mosquito cells.
|
30650347 |
2019 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Release of Soluble Insulin Receptor From Neurons by Cerebrospinal Fluid From Patients With Neurocognitive Dysfunction and HIV Infection.
|
30972014 |
2019 |
|
Hypercholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Testosterone improves metabolic CV risk factors including body composition, insulin resistance, and hypercholesterolemia by improving both glucose utilization and lipid metabolism by a combination of genomic and nongenomic actions of glucose uptake and utilization expression of the insulin receptor, glucose transporters, and expression on regulatory enzymes of key metabolic pathways.
|
29442075 |
2019 |
|
Impulsive Behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Across multiple samples (n = 4502), the biologically informed, mesocorticolimbic or hippocampal specific insulin receptor polygenic scores were calculated, and their ability to predict impulsivity, risk for addiction, cognitive performance and presence of Alzheimer's disease was investigated.
|
30922963 |
2019 |
|
Vitamin D Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D deficiency itself also led to decreased LC3 II levels in the liver and decreased insulin receptor staining in the ovaries.
|
31509973 |
2019 |
|
Addictive Behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Across multiple samples (n = 4502), the biologically informed, mesocorticolimbic or hippocampal specific insulin receptor polygenic scores were calculated, and their ability to predict impulsivity, risk for addiction, cognitive performance and presence of Alzheimer's disease was investigated.
|
30922963 |
2019 |
|
Metabolic alkalosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Insulin receptor-related receptor (IRR) is a receptor tyrosine kinase of the insulin receptor family and functions as an extracellular alkali sensor that controls metabolic alkalosis in the regulation of the acid-base balance.
|
31615897 |
2019 |
|
Zika Virus Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, siRNA-mediated knockdown and treatment with a small-molecule inhibitor of the insulin receptor kinase concur to assign a crucial role for this enzyme in the replication of dengue and Zika viruses in cultured mosquito cells.
|
30650347 |
2019 |
|
Neuroglycopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GLUT4-Cre-driven insulin receptor knockout mice with a combined ablation of IR in Glut4-expressing tissues showed increased counterregulatory response to either 2-deoxyglucose-induced neuroglycopenia or systemic insulin-induced hypoglycemia.
|
31199472 |
2019 |
|
Complement component 5 deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
These changes were not due to the C5 deficiency alone as other C5-deficient models did not recapitulate the INSR processing defect; rather, in addition to the mutation in the <i>C5</i> gene, whole genome sequencing revealed an intronic 31-bp deletion in the <i>Insr</i> gene in the B10.D2-<i>Hc<sup>0</sup> H2<sup>d</sup> H2</i>-<i>T18<sup>c</sup></i>/oSnJ model.
|
31084499 |
2019 |
|
Recurrent tumor
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Risk of tumor recurrence positively correlated with AS isoform of the INSR gene.
|
31140152 |
2019 |
|
Endothelial dysfunction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major negative regulator for insulin receptor signaling and a novel molecular player in endothelial dysfunction and cardiovascular disease.
|
31319588 |
2019 |
|
Major Depressive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Network analysis revealed distinct gene modules enriched in signaling pathways related to stress responses, neuron apoptosis, insulin receptor signaling, mTOR signaling, and nerve growth factor receptor signaling, suggesting potential functional relevance to MDD.
|
31477685 |
2019 |
|
Adenocarcinoma of the gastroesophageal junction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified that TCF7L2 rs290481, INS rs689, and INSR rs1799817 SNPs increased the susceptibility of AEG in different cancer stage subgroups.
|
31211453 |
2019 |
|
Skin Carcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, we identified a unique pathway in which IR regulates cytoskeletal assembly, thus affecting skin transformation, opening a new potential target for cancer treatment and prevention.-Weingarten, G., Ben Yaakov, A., Dror, E., Russ, J., Magin, T. M., Kahn, C. R., Wertheimer, E. Insulin receptor plays a central role in skin carcinogenesis by regulating cytoskeleton assembly.
|
30332298 |
2019 |
|
Partial lipodystrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Both patients had partial lipodystrophy and a novel heterozygous missense mutation (Asn<sup>1137</sup> → Lys<sup>1137</sup>) in the insulin receptor gene.
|
31102683 |
2019 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Insulin receptor sensitization restores neocortical excitation/inhibition balance in a mouse model of autism.
|
29484150 |
2018 |
|
Malignant neoplasm of thyroid
|
0.010 |
Biomarker
|
disease |
BEFREE |
The Emerging Role of Insulin Receptor Isoforms in Thyroid Cancer: Clinical Implications and New Perspectives.
|
30513575 |
2018 |
|
Carcinoma, Papillary
|
0.010 |
Biomarker
|
disease |
BEFREE |
They also reveal an important reciprocal relationship between IR/IGF-1R and TSH/ErbB signaling in the pathogenesis of thyroid follicular hyperplasia and, possibly, of papillary carcinoma.
|
30070361 |
2018 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain.
|
30278200 |
2018 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain.
|
30278200 |
2018 |
|
Graves Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Yangxin Tongmai Formula ameliorates impaired glucose tolerance in children with Graves' disease through upregulation of the insulin receptor levels.
|
29168473 |
2018 |
|
Hunger
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In humans, reduced representation bisulfite sequencing (RRBS) was performed on peripheral samples that were obtained from individuals who were prenatally exposed to the "Dutch Hunger Winter", resulting in two Differentially Methylated Regions (DMRs) in INSR and CPTIA genes that were functionally, biologically and technically validated, and significantly associated with birth weights and LDL cholesterol levels in offspring.
|
30532646 |
2018 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a model of severe influenza infection with A/PR8 (H1N1), lack of insulin receptor on T cells curtails antigen-specific immunity to influenza viral antigens.
|
30174303 |
2018 |