|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that cone snails have evolved diverse strategies to activate the vertebrate insulin receptor and provide unique insight into the design of novel drugs for the treatment of diabetes.
|
30747102 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes.
|
30453495 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In mice, the deletion of insulin receptor substrate type 2 (Irs2) causes peripheral insulin resistance and reduction in β-cell mass, leading to overt diabetes, with gender differences on adrenergic signaling.
|
30367392 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that leflunomide sensitizes the insulin receptor by inhibiting S6K1 activity <i>in vitro</i>, and that leflunomide could be potentially useful for treating patients with both RA and diabetes.
|
29496905 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.
|
29435980 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.
|
29512653 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of Western blot validation showed that dynamic changes in proteins, such as IGF2, Ly6a, Grb10, and UBD, occurred to regulate the incidence of diabetes by influencing the insulin receptor substrate (IRS) signaling pathway.
|
30131712 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Type B insulin resistance due to autoantibodies against the insulin receptor is characterized by diabetes refractory to massive doses of insulin, severe hypercatabolism, hyperandrogenism, and a high mortality rate.
|
30201849 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes.
|
30356040 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth factor signaling via insulin receptor (IR) and IGF-1 receptor (IGF1R) plays several important roles in the pathogenesis of metabolic syndrome and diabetes.
|
28646158 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also, GLUT4, insulin receptor (IRβ), acetyl coenzyme A (ACC), etc. increased in fat pad of maternal offspring of diabetes.
|
28925477 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Future research with new IR modulators might be considered as possible targets to improve the treatment of diabetes and its associated complications.
|
29201918 |
2017 |
|
Diabetes
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes.
|
28346406 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate the novel role of placental InsRs in sex-specific neurodevelopment and reveal a potential mechanism for neurodevelopmental disorder risk in pregnancies complicated by maternal metabolic disorders, including diabetes and obesity.
|
28168960 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to introduce the foreskin as a novel model to examine developmental programming in human neonates, particularly in regard to adipogenesis and insulin receptor signaling, major contributors to age-associated diseases such as obesity and diabetes.
|
28034763 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling.
|
28192884 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also focus on novel IR ligands and modulators that should now be considered as an important strategy for better and safer treatment of diabetes and cancer and possibly other IR-related diseases.
|
28973479 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Based on network analysis, we identified enrichment for pathways implicated in metabolic syndrome and diabetes (insulin receptor signaling, lipid metabolism, immunity and trafficking).
|
28886276 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diabetes was induced by tetracycline-inducible small hairpin RNA (shRNA) knockdown of the insulin receptor in rats, generating TetO rats.
|
27704165 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
IR is expressed in all tissues, but it is not known if diabetes affects IR in all tissues equally.
|
26921319 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes.
|
26387534 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rational drug design aimed at treatment of diabetes relies on knowledge of the detailed structure of IR and the dynamic structural transformations during transmembrane signaling.
|
26322622 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include 'insulin receptor binding', and 'negative regulation of glucose import' which are associated with diabetes, 'positive regulation of interleukin-6-mediated signaling pathway', 'regulation of T-helper 2 cell differentiation', 'positive regulation of interleukin-13 production' which are associated with the immune system and 'sertoli cell fate commitment' which is important for male fertility.
|
24334605 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report for the first time that expression of the insulin receptor (IR) in human kidney is altered during diabetes.
|
23059533 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rodents with tissue-specific knockout of the insulin receptor in the β-cell (βIRKO) show reduced first-phase glucose-stimulated insulin secretion (GSIS) and with aging develop glucose intolerance and diabetes, phenotypically similar to the process seen in human T2D.
|
22928576 |
2012 |