Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The increased insulin sensitivity responsiveness in Grb10-silenced myotubes was associated with higher abundance of the insulin receptor.
|
31794259 |
2020 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
To determine whether obesity-associated hyperinsulinemia promotes bone growth by activating the insulin receptor in the growth plate, we generated <sup>TamCart</sup>IR<sup>flox/flox</sup> mice.
|
30798001 |
2019 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
This is a highly significant observation because it is the first to show that systemic hyperinsulinemia can suppress autophagy in IR-deficient hearts through IGF-1R signaling.
|
31088290 |
2019 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Acute induction of insulin receptor knockout in adipocytes changed the substrate preference to fat before induction of a diabetic phenotype including hyperinsulinaemia and hyperglycaemia.
|
31309261 |
2019 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Additionally, both mRNA expressions and protein levels of insulin increased significantly in the 10 and 100 μg/L exposure groups, while transcription levels of genes encoding insulin receptor substrates decreased significantly in these groups, indicating a possibly decreased insulin sensitivity due to impairment of insulin signaling transduction downstream of insulin receptor.
|
30218961 |
2018 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
In type 2 diabetic mice, taurine decreases blood glucose through increased insulin secretion and insulin receptor sensitization.
|
29710660 |
2018 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Both acute and chronic exposure of MC-LR, even at very low concentrations (1 μg/L), impaired the insulin receptor signalling pathway and induced hyperinsulinemia and insulin resistance in mice.
|
29777831 |
2018 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The combination of fasting hyperinsulinemia with acanthosis nigricans in a lean subject with hypoglycemia suggests severe insulin resistance and warrants INSR gene screening.
|
29411486 |
2018 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the reduction of macrophage Irs2 expression is mediated by hyperinsulinemia via the insulin receptor (IR).
|
30451856 |
2018 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
These podocytes lose expression of the IR as a direct consequence of prolonged exposure to high insulin concentrations, which causes an increase in IR protein degradation via a proteasome-dependent and bafilomycin-sensitive pathway.
|
28852804 |
2017 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We concluded that vitamin D3 ameliorated insulin resistance and hyperinsulinemia in diabetic rat model received HFW through reduction of IDE and activation of insulin receptor phosphorylation.
|
27930980 |
2017 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expression of the insulin receptor (IR) signaling cascade, including IR, IR substrate, phosphatidylinositol 3-kinase, Akt, and glucose transporter 4, was inhibited both in the skeletal muscle and the liver, which might be a main reason for the hyperglycemia and hyperinsulinemia.
|
28397090 |
2017 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
TRG (50 mg/kg; p.o) lowered serum glucose, fructosamine, insulin, and HOMA-IR index and increased insulin sensitivity in soleus muscle via augmenting insulin receptor autophosphorylation (IR-PH), pT308-Akt, and glucose transporter 4 (GLUT4).
|
28271502 |
2017 |
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A 29-year-old woman developed an autoantibody to the insulin receptor (type B insulin resistance), causing extreme insulin resistance and hyperinsulinemia.
|
27911591 |
2017 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-1β and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1β mediated by the NLRP3 inflammasome.
|
28092375 |
2017 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Decreased IR expression in high‑stage RCC tumors with poor prognosis may be the result of downregulation induced by the host's hyperinsulinemia.
|
28393204 |
2017 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Circulating IR-A and IR-B bioactivities are associated with insulin resistance, high insulin requirements, and poor glycemic control in T1D.
|
28938465 |
2017 |
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Donohue syndrome ([DS]; leprechaunism) describes a genetic autosomal recessive disorder that results from the presence of homozygous or compound heterozygous mutations in the insulin receptor gene (INSR; 19p13.3-p13.2).Donohue syndrome is associated with a fatal congenital form of dwarfism with features of intrauterine and postnatal growth retardation, exaggerated hyperglycemia with hyperinsulinism and dysmorphic abnormalities.We present a case of DS owing to the rarity of this syndrome (1 case in every million births).
|
26871809 |
2016 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
|
27435064 |
2016 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We characterised expression of IR-related molecules, IRS-1 phosphorylation and downstream signalling in a panel of 5 colon cancer cell lines at different insulin exposures: 15 min (100 nM), approximating to acute stimulation; 48 h (100 nM), used to demonstrate adaptive changes; and 12 weeks (20 nM; chronic insulin exposure, CIE), approximating to chronic hyperinsulinaemia.
|
24068609 |
2014 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of IR-A during neoplastic transformation of hepatocytes could mediate some of the adverse effects of hyperinsulinemia on HCC.
|
23633480 |
2013 |
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
INSR mutations can be also found in pubertal females with hyperinsulinism, hyperandrogenism, and acanthosis nigricans (type A SIR).
|
23824322 |
2013 |
Hyperinsulinism
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Animal studies have suggested that SH2B1 is a physiological enhancer of the insulin receptor and humans with rare deletions or mutations at SH2B1 are obese with a disproportionately high insulin resistance.
|
24103803 |
2013 |
Hyperinsulinism
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Using RT-PCR, we found that visfatin did not regulate IR expression and that an increased insulin release was also unlikely to be involved because insulin was unable to increase PGE(2) release.
|
22399297 |
2012 |
Hyperinsulinism
|
0.500 |
Biomarker
|
disease |
BEFREE |
Sequencing demonstrated INSR haploinsufficiency accounting for elevated insulin levels and dysglycemia.
|
19720790 |
2009 |