|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Insulin restores these alterations in GDM via activation of insulin receptor A (IR-A) form in the macrovascular but IR-A and IR-B forms in the microcirculation of the human placenta.
|
30660686 |
2020 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
We evaluated IR mRNA and protein expression accompanied by targeted DNA methylation analyses in AT and blood cells of women with GDM and their offspring.
|
30260402 |
2019 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In liver at 31 weeks, mRNA levels of peroxisome proliferator-activated receptor alpha (Ppara) were elevated in CD-fed male offspring of GDM dams, and male offspring of GDM dams exhibited higher mRNA levels of Insr on both diets.
|
30698664 |
2019 |
|
Gestational Diabetes
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
Two miR-binding SNPs SLC30A8 rs2466293 and INSR rs1366600 increased GDM susceptibility.
|
28190110 |
2017 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
There was a decrease in GLUT-3 and insulin receptor substrate (IRS)-1 protein expression and lower IRS-2 mRNA expression was also observed in GDM placental tissue.
|
27497146 |
2016 |
|
Gestational Diabetes
|
0.300 |
PosttranslationalModification
|
phenotype |
BEFREE |
However, the phosphorylation of IR and the downstream elements were significantly lower in GDM-trophoblast and showed no response to the insulin stimulation while they showed 4-fold increase to insulin stimulation in control group.
|
26921319 |
2016 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium.
|
25351985 |
2015 |
|
Gestational Diabetes
|
0.300 |
Biomarker
|
phenotype |
RGD |
We examined the effects of maternal diabetes on insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (InsR) expression in the developing rat hippocampus.
|
22241286 |
2013 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Cells from GDM exhibited increased insulin receptor A isoform expression in addition to the reported NO-dependent inhibition of hENT1-adenosine transport and SLC29A1 reporter repression, and increased extracellular concentration of adenosine and NO synthase activity.
|
21515851 |
2011 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
This study demonstrated altered mRNA expression of insulin receptor substrate (IRS)-1, IRS-2, glucose transporter (GLUT)-1, GLUT-4 and glycogen synthase kinase (GSK)-3 isoforms genes in adipose tissue in GDM women in comparison to NGT pregnant controls.
|
19955252 |
2010 |
|
Gestational Diabetes
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
There was a significant increase in insulin receptor (IR) substrate (IRS)-1 protein expression with a concurrent decrease in IRS-2 protein expression in non-obese women with insulin-controlled GDM compared with diet-controlled GDM and normal controls.
|
19179458 |
2009 |
|
Gestational Diabetes
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Adipose tissue insulin receptor substrate (IRS)-1 protein levels were 43% lower (P = 0.02) and p85alpha subunit of phosphatidylinositol 3-kinase was twofold higher (P = 0.03) in GDM compared with Preg-Con subjects.
|
11832353 |
2002 |
|
Gestational Diabetes
|
0.300 |
PosttranslationalModification
|
phenotype |
BEFREE |
Similarly, insulin receptor tyrosine phosphorylation was significantly decreased in subjects with GDM (P < 0.05) compared with pregnant and nonpregnant control subjects.
|
10871198 |
2000 |
|
Gestational Diabetes
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the single mutant db allele effects susceptibility to GDM through abnormalities in insulin receptor signaling, defective insulin secretion, and greater nutrient availability.
|
10331411 |
1999 |
|
Gestational Diabetes
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Insulin receptor binding to target tissues is largely unaffected by normal and GDM pregnancy; the same is true for basal and insulin-stimulated insulin receptor-bound tyrosine kinase activity.
|
9704223 |
1998 |
|
Gestational Diabetes
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
Among Caucasian subjects, a similar relationship between the INSR allele 1 (P = 0.007) and INSR allele 1-BMI interactions (P = 0.011) on GDM risk were observed.
|
2574127 |
1989 |