INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 Biomarker phenotype BEFREE Previously published work has demonstrated that overexpression of the insulin receptor isoform A (IR-A) might play a role in cancer progression and metastasis. 31480557 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 Biomarker phenotype BEFREE Insulin receptor isoform A favors tumor progression in human hepatocellular carcinoma by increasing stem/progenitor cell features. 30849481 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 AlteredExpression phenotype BEFREE The IR isoform overexpression may play a role in cancer cell stemness, in tumor progression and in resistance to target therapies. 30453495 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 Biomarker phenotype BEFREE INSR may therefore represent a novel biomarker to predict cancer progression. 28295307 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 Biomarker phenotype BEFREE The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition. 27435064 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 AlteredExpression phenotype BEFREE These epidemiological data motivated us to determine, by means of immunohistochemistry, the amount of activated (phosphorylated) insulin receptor in archival samples from 22 colorectal adenoma and 117 adenocarcinoma patients, with the objective to estimate the role of this factor in colorectal epithelium transformation and cancer progression. 25102778 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.070 Biomarker phenotype BEFREE Despite mounting evidence that the highly homologous insulin receptor (IR) can also convey protumorigenic signals, its direct role in cancer progression has not been genetically defined in vivo, and it remains unclear whether such a role for IR signaling could compromise the efficacy of selective IGF-1R targeting strategies. 20457905 2010