INSR, insulin receptor, 3643

N. diseases: 452; N. variants: 109
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 AlteredExpression disease BEFREE We investigated IGF1R and IR expression and its association with lethal prostate cancer among 769 men. 30165429 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 Biomarker disease BEFREE Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo. 26452103 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 Biomarker disease BEFREE The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. 25267499 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 Biomarker disease BEFREE Our study underscores the oncogenic impact of IGF1R including significant effects on tumor growth, cell migration, sensitivity to apoptotic/chemotherapeutic agents and angiogenesis, and characterizes the INSR, in particular the isoform INSRA, as additional cancer-promoting receptor in prostate cancer. 24809298 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 Biomarker disease BEFREE IGF2 mRNA but not IGF2 receptor mRNA expression was increased in patient samples during progression to castrate-resistant PC as was immunoreactivity to INSR and IGF1R antibodies. 23319492 2013
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 AlteredExpression disease BEFREE Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer. 23251408 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 GeneticVariation disease BEFREE We aimed to examine the association of INSR H1085H C>T and IRS1 G972R polymorphisms with prostate cancer (PC). 21204696 2011
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.080 AlteredExpression disease BEFREE Analysis of information from public gene expression databases confirmed that co-expression of insulin receptor mRNA and IGF-I receptor mRNA is common in prostate cancer specimens. 18785179 2009