PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease HPO
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease RGD Prevention of hyperglycemia prevented the associated defects in insulin and PDX-1 gene expression and improved insulin secretion. 10512364 1999
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Hepatic immunoreactive insulin, induced by PDX-1, was processed to mature mI-1 and mI-2 and was biologically active; it ameliorated hyperglycemia in streptozotocin-treated diabetic mice. 10909415 2000
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Patients with mutation in genes encoding the transcription factors, hepatocyte nuclear factor (HNF)- 1alpha, HNF-4alpha, HNF-1beta and insulin promoter factor 1 (IPF-1) have a common progressive beta-cell failure resulting in increasing hyperglycaemia and treatment requirements. 12173691 2002
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease RGD At the same time points, high hyperglycemia rats showed a global alteration in gene expression with decreased mRNA for insulin, IAPP, islet-associated transcription factors (pancreatic and duodenal homeobox-1, BETA2/NeuroD, Nkx6.1, and hepatocyte nuclear factor 1 alpha), beta-cell metabolic enzymes (glucose transporter 2, glucokinase, mitochondrial glycerol phosphate dehydrogenase, and pyruvate carboxylase), and ion channels/pumps (Kir6.2, VDCC beta, and sarcoplasmic reticulum Ca(2+)-ATPase 3). 12438314 2003
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 AlteredExpression disease BEFREE While acute exposure to high glucose concentrations causes an increase in PDX-1 binding, and consequently in insulin mRNA levels, chronic hyperglycemia (toxic to the beta-cell) leads to a decrease in PDX-1 and insulin levels. 12503852 2003
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice. 19757377 2010
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE PDX-1 was decreased in MIN6N8 cells treated with high glucose or high palmitate, whereas ATF3 was increased, indicating that ATF3 plays a role in hyperglycemia or hyperlipidemia-mediated downregulation of PDX-1 expression. 21821004 2011
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 PosttranslationalModification disease BEFREE Our data further indicate that hyperglycemia decreases gene expression and increases DNA methylation of PDX-1 because glycosylated hemoglobin (HbA1c) correlates negatively with mRNA expression (rho = -0.50, P = 0.0004) and positively with DNA methylation (rho = 0.54, P = 0.00024) of PDX-1 in the human islets. 22570331 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Human BMSCs expressing VEGF and PDX1 reversed hyperglycemia in more than half of the diabetic mice and induced overall improved survival and weight maintenance in all mice. 22879915 2012
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Hyperglycemia recurred within 24 hours of graft removal and the histological analysis of the retrieved grafts revealed presence of Pdx1-, Nkx6.1- and C-peptide-positive cells. 23671681 2013
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 AlteredExpression disease BEFREE On the contrary, despite normal pancreas and endocrine development, the FVFPBF<sup>DHom</sup> reporter male animals developed hyperglycemia at weaning age and displayed a reduction in Pdx1 levels in islets, which coincided with alterations in β-cell number and islet architecture. 28580283 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 AlteredExpression disease BEFREE Compromised Pdx1 mRNA and protein levels in weaned male mutant β-cells were tightly linked with hyperglycemia, decreased β-cell proliferation, reduced β-cell area, and altered expression of Pdx1-bound genes that are important in β-cell replication, endoplasmic reticulum function, and mitochondrial activity. 28705881 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 Biomarker disease BEFREE Islets of JNK-1-null mice exposed to hyperglycemia in vivo showed an increase in Pdx-1 and insulin 2 mRNA, whereas islets of wild-type mice did not. 30215691 2018
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.400 AlteredExpression disease BEFREE The suppression of STAT3 signaling, together with exogenously expressed Pdx1, Neurog3, and Mafa, significantly increased the number of reprogrammed β cells in vitro and in vivo, enhanced the formation of islet-like clusters in mice, and ameliorated hyperglycemia in diabetic mice. 30266298 2018