|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that GPR120 activation is protective against lipotoxicity-induced pancreatic β-cell dysfunction, via the mediation of PDX1 expression and inhibition of islet inflammation, and that GPR120 activation may serve as a preventative and therapeutic target for obesity and diabetes.
|
30523046 |
2019 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results reveal mechanistic details of how common coding mutations in PDX1 impair human pancreatic endocrine lineage formation and β-cell function and contribute to the predisposition for diabetes.
|
30930126 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated β-cell stress levels promote severe diabetes development in mice with MODY4.
|
31682591 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, it also modulated the expression of peroxisome proliferator-activated receptor γ (PPARγ) and pancreatic and duodenal homeobox 1 (PDX-1).Our findings showed that <i>A. annulatum</i> and its bioactive compounds are capable of improving insulin secretion by pancreatic β-cells.This suggests that <i>A. annulatum</i> can be used as a therapeutic agent to treat diabetes.
|
31382473 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data provide stage-specific target genes of PDX1 during in vitro differentiation of stem cells into pancreatic progenitors that could be useful to identify pathways and molecular targets that predispose for diabetes.
|
29396371 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The unusual presentation in this Brazilian family enabled expansion upon a rare disease phenotype, demonstrating the possibility of detecting pancreatic malformation even in cases of PDX1 -related diabetes diagnosed after the first year of life.
|
28436541 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Zinc deficiency was also associated with decreased expression of genes related to diabetes and pancreatic development in the embryo (Insa, Pax4, Pdx1).
|
28268202 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Teucrium polium extract reverses symptoms of streptozotocin-induced diabetes in rats via rebalancing the Pdx1 and FoxO1 expressions.
|
28738518 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A positive effect of a β-adrenergic agonist on RAF-1 and PDX-1, reduction in β-cell apoptosis and improved insulin contents can help to understand the pathogenesis of diabetes and to develop novel approaches for the β-cell dysfunction in diabetes.
|
28261303 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene.
|
27879214 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1), which is critical for insulin production.Pre-clinical studies in various animal models of diabetes have reported that MST1 deficiency remarkably restores normoglycaemia and beta cell function and prevents the development of diabetes.
|
27053234 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we examined these questions by testing the ability of hBMSCs genetically modified to transiently express vascular endothelial growth factor (VEGF) or pancreatic-duodenal homeobox 1 (PDX1) to reverse diabetes and whether these cells were differentiated into β-cells or mediated recovery through alternative mechanisms.
|
22879915 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes.
|
22570331 |
2012 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a novel mutation in the pancreatic and duodenal homeobox 1 gene (PDX1, IPF1) in the two patients, which segregated with diabetes in the homozygous state.
|
20009086 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results establish Nix as a critical mediator of β cell apoptosis and programmed necrosis in Pdx1-deficient diabetes.
|
20978346 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.
|
20479245 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several studies showed that stress can stimulate autophagy in β-cells: the number of autophagosomes is increased in different in vivo models for diabetes, such as db/db mice, mice fed high-fat diet, pdx-1 knockout mice, as well as in in vitro models of glucotoxicity and lipotoxicity.
|
21029295 |
2010 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This property of PDX-1 opens new strategies for the treatment of diabetes.
|
18360684 |
2008 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicated that the Pdx1 functioned as a key regulator for maintenance of beta-cell function, at least in part, through controlling c-Myc expression and the loss of its regulatory function may be an alternative mechanism for beta-cell neogenesis and apoptosis found in diabetes.
|
17317781 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach.
|
17131142 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, PDX-1 and MafA play a crucial role in inducing surrogate beta-cells and could be a therapeutic target for diabetes.
|
17449132 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An earlier French study identified InsCCG243 as a cause of autosomal dominant diabetes.
|
17003361 |
2006 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We screened 264 unrelated subjects with type 2 diabetes diagnosed before 40 yr of age and a family history of diabetes for mutations in the minimal promoter and coding region of the IPF-1 gene (IPF1).
|
14764823 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Impairment of interactions between PDX-1 and p300 in pancreatic beta-cells may limit insulin production and lead to the development of diabetes.
|
15001545 |
2004 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The D76N variant of PDX1 does not significantly alter insulin secretion or act as a high-risk susceptibility allele for late-onset type 2 diabetes as proposed previously, although we cannot exclude a minor role in increasing risk of diabetes.
|
15277425 |
2004 |