PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Disease: insulinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE To demonstrate this, we used pMAGIC to target Sa-dCas9/LSD1 and modify the epigenetic status of a conserved enhancer, resulting in altered expression of the homeobox transcription factor PDX1 and its target genes in pancreatic islets and insulinoma cells. 30590691 2019
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE Our previous studies have shown that a rat insulin promoter II fragment (RIP) was used to effectively target pancreatic adenocarcinoma (PDAC) and insulinoma that over-express pancreatic and duodenal homeobox-1 (PDX-1). 29309817 2018
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE SSTR5 knockdown by short hairpin RNA led to increased PDX-1 expression that was accompanied by enhanced insulin secretion stimulated by high glucose in β-TC6 cells and alternated expressions of cell cycle proteins that favor cell proliferation in mouse insulinoma MIN6 cells. 22669743 2012
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE Deregulated Ran signaling in transgenic mice, adenoviral over-expression of WT or mutant Ran in isolated islets, or short hairpin RNA (shRNA) silencing of endogenous Ran in model insulinoma INS-1 cells, all resulted in decreased expression of the pancreatic and duodenal homeobox transcription factor, PDX-1, and reduced β cell proliferation, in vivo. 22114719 2011
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 Biomarker disease BEFREE Pdx1 autoantibodies (PAAs) were detected in non-obese diabetic (NOD) mice using ELISA, western blotting, and radioimmunoprecipitation of [(35)S]-labeled insulinoma cell line-derived Pdx1 protein. 19901909 2010
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 Biomarker disease BEFREE We show that lentiviral suppression of Pdx1 increases death of mouse insulinoma MIN6 beta-cells associated with dissipation of the mitochondrial inner membrane electrochemical gradient, Deltapsi(m). 20479245 2010
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE In this study, we introduced an shRNA into mouse insulinoma MIN6 cells to deplete Pdx1 and found that expression of proapoptotic genes, including NIP3-like protein X (Nix), was increased. 20978346 2010
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 Biomarker disease BEFREE Insulinomas had significantly higher PDX1 and DLK1 messenger RNA levels compared with other tumor types. 19307926 2009
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 Biomarker disease BEFREE In previous studies, we demonstrated that rat insulin promoter (RIP)-driven gene therapy successfully targeted human pancreatic tumor PANC-1 cells and mouse insulinoma NIT-1 cells, which are both pancreatic duodenal homeobox-1 (PDX-1)-positive. 15706433 2005
CUI: C0021670
Disease: insulinoma
insulinoma 		0.100 AlteredExpression disease BEFREE When the AR42J cells were converted into insulin-positive cells induced by GLP-1, insulinoma conditioned-medium, or both, we observed a significant elevated expression of mRNA for IA-1 and islet-specific transcription factors such as Pdx-1, NeuroD/beta2, and Nkx6.1. 11854618 2002