Pancreatic Neoplasm
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
It is now well known that the undifferentiated PDX1+ pancreatic progenitors proliferate and differentiate into endocrine, ductal, and acinar cells, thanks to the expression of numerous transcription factors, which can be used to better characterize pancreatic tumors.
|
30130629 |
2019 |
Pancreatic Neoplasm
|
0.380 |
Biomarker
|
disease |
BEFREE |
Increasing Hh expression in neoplastic cells added desmoplastic stroma accumulation in orthotopic tumors, and Hh inhibitors that target the stroma have an ability to prolong the overall survival of Pdx-1-Cre/KrasG12D/p53R172H mice models via deleting the stromal components and increasing vascularity in pancreatic tumor.
|
29521941 |
2018 |
Pancreatic Neoplasm
|
0.380 |
Biomarker
|
disease |
BEFREE |
We investigated the preclinical activity of STA-12-8666 in patient derived xenograft and genetic models of pancreatic cancer.Treatment with STA-12-8666 of the KPC mice (knock-in alleles of LSL-KrasG12D, Tp53fl/fl and Pdx1-Cre transgene) at the advanced stages of pancreatic tumors doubled their survival (49 days vs. 74 days, p=0.008).
|
27779106 |
2017 |
Pancreatic Neoplasm
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors.
|
26408346 |
2016 |
Pancreatic Neoplasm
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Deletion of Lfng resulted in downregulation of Tgfb1, Tgfb2 and Tgfbr2 expression in the wild-type pancreas at all ages examined, and in the Kras(LSL-G12D/+);Pdx1-Cre pancreas after PDAC onset, as well as reduced phospho-Smad2 levels in pancreatic tumors.
|
26279302 |
2016 |
Pancreatic Neoplasm
|
0.380 |
Biomarker
|
disease |
CTD_human |
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
|
26098869 |
2015 |
Pancreatic Neoplasm
|
0.380 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
|
25086665 |
2014 |
Pancreatic Neoplasm
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
Pancreatic Neoplasm
|
0.380 |
Biomarker
|
disease |
CTD_human |
The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer.
|
19077462 |
2009 |
Pancreatic Neoplasm
|
0.380 |
AlteredExpression
|
disease |
LHGDN |
PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer.
|
18665085 |
2008 |
Pancreatic Neoplasm
|
0.380 |
AlteredExpression
|
disease |
LHGDN |
Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer.
|
12947327 |
2003 |