PDX1, pancreatic and duodenal homeobox 1, 3651

N. diseases: 185; N. variants: 22
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 AlteredExpression disease BEFREE It is now well known that the undifferentiated PDX1+ pancreatic progenitors proliferate and differentiate into endocrine, ductal, and acinar cells, thanks to the expression of numerous transcription factors, which can be used to better characterize pancreatic tumors. 30130629 2019
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 Biomarker disease BEFREE Increasing Hh expression in neoplastic cells added desmoplastic stroma accumulation in orthotopic tumors, and Hh inhibitors that target the stroma have an ability to prolong the overall survival of Pdx-1-Cre/KrasG12D/p53R172H mice models via deleting the stromal components and increasing vascularity in pancreatic tumor. 29521941 2018
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 Biomarker disease BEFREE We investigated the preclinical activity of STA-12-8666 in patient derived xenograft and genetic models of pancreatic cancer.Treatment with STA-12-8666 of the KPC mice (knock-in alleles of LSL-KrasG12D, Tp53fl/fl and Pdx1-Cre transgene) at the advanced stages of pancreatic tumors doubled their survival (49 days vs. 74 days, p=0.008). 27779106 2017
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 GeneticVariation disease BEFREE We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors. 26408346 2016
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 GeneticVariation disease BEFREE Deletion of Lfng resulted in downregulation of Tgfb1, Tgfb2 and Tgfbr2 expression in the wild-type pancreas at all ages examined, and in the Kras(LSL-G12D/+);Pdx1-Cre pancreas after PDAC onset, as well as reduced phospho-Smad2 levels in pancreatic tumors. 26279302 2016
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 Biomarker disease CTD_human Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. 26098869 2015
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 Biomarker disease CTD_human Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. 25086665 2014
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 GeneticVariation disease BEFREE In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival. 23980075 2013
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 Biomarker disease CTD_human The expression pattern of PDX-1, SHH, Patched and Gli-1 is associated with pathological and clinical features in human pancreatic cancer. 19077462 2009
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 AlteredExpression disease LHGDN PDX-1 acts as a potential molecular target for treatment of human pancreatic cancer. 18665085 2008
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.380 AlteredExpression disease LHGDN Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer. 12947327 2003