|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
BEFREE |
MTMR2 mediated EMT through the IFNγ/STAT1/IRF1 pathway to promote GC invasion and metastasis.
|
31113461 |
2019 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
BEFREE |
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
|
31186404 |
2019 |
|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
SNP rs56288038 (C/G) in IRF-1 3'UTR was involved in the occurrence of GC by acting as a tumor promoter factor.
|
27866197 |
2016 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
BEFREE |
We used these clones and recombinant adenovirus expressing IRF-1 to explore the mechanism of IRF-1-induced apoptosis in gastric cancer.
|
19851330 |
2010 |
|
Malignant neoplasm of stomach
|
0.660 |
GeneticVariation
|
disease |
BEFREE |
The interferon regulatory factor-1 (IRF1) gene, localized on chromosome 5q31.1, is mutated or rearranged in several cancers including some hematopoietic and gastric cancers.
|
19697121 |
2010 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
BEFREE |
These results suggest that the loss of functional IRF-1 is critical for the development of human gastric cancers.
|
9679752 |
1998 |
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of stomach
|
0.660 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of stomach
|
0.660 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Stomach Carcinoma
|
0.650 |
Biomarker
|
disease |
BEFREE |
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
|
31186404 |
2019 |
|
Stomach Carcinoma
|
0.650 |
Biomarker
|
disease |
BEFREE |
MTMR2 mediated EMT through the IFNγ/STAT1/IRF1 pathway to promote GC invasion and metastasis.
|
31113461 |
2019 |
|
Stomach Carcinoma
|
0.650 |
GeneticVariation
|
disease |
BEFREE |
SNP rs56288038 (C/G) in IRF-1 3'UTR was involved in the occurrence of GC by acting as a tumor promoter factor.
|
27866197 |
2016 |
|
Stomach Carcinoma
|
0.650 |
Biomarker
|
disease |
BEFREE |
We used these clones and recombinant adenovirus expressing IRF-1 to explore the mechanism of IRF-1-induced apoptosis in gastric cancer.
|
19851330 |
2010 |
|
Stomach Carcinoma
|
0.650 |
GeneticVariation
|
disease |
UNIPROT |
Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding.
|
10395927 |
1999 |
|
Stomach Carcinoma
|
0.650 |
GeneticVariation
|
disease |
UNIPROT |
Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.
|
9679752 |
1998 |
|
Stomach Carcinoma
|
0.650 |
GeneticVariation
|
disease |
BEFREE |
Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.
|
9679752 |
1998 |
|
Stomach Carcinoma
|
0.650 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Stomach Carcinoma
|
0.650 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Stomach Neoplasms
|
0.600 |
CausalMutation
|
group |
CLINVAR |
|
|
|
|
Stomach Neoplasms
|
0.600 |
CausalMutation
|
group |
CGI |
|
|
|
|
Stomach Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
|
|
|
|
Leukemia, Myelocytic, Acute
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Involved in regulation of differentiation and proliferation, IRF-1 acts as a tumor suppressor gene and is inactivated by deletion of its one or more exons (exon skipping) in many hematological malignancies, including acute myelocytic leukemia (AML) and myelodysplastic syndromes (MDS).
|
21790247 |
2011 |
|
Leukemia, Myelocytic, Acute
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Clinically, approximately 70% of cases of acute myeloid leukaemia demonstrate dysregulated expression of IRF1 and/or IRF2.
|
18575764 |
2008 |
|
Leukemia, Myelocytic, Acute
|
0.380 |
Biomarker
|
disease |
BEFREE |
The skipping of exons 2 or 2 and 3 of IRF-1 in patients with myelodysplastic syndromes and acute myelogenous leukaemia suggests that this factor may have a critical role in leukaemogenesis.
|
12358902 |
2002 |
|
Leukemia, Myelocytic, Acute
|
0.380 |
Biomarker
|
disease |
BEFREE |
Of approximately 1400 genes analyzed, 2 tumor-suppressor genes were identified that were overexpressed in all 7 of the AML CD34(+)/CD38(-) cell populations: death-associated protein kinase and interferon regulatory factor 1.
|
11264190 |
2001 |