Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
The disruption of IRF6 resulted in abnormal orofacial development including micrognathia and intraoral adhesions as well as tongue-palate fusion, then resulting in glossoptosis with airway obstruction and cleft palate.
|
29708799 |
2019 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IRF6 rs2235375 single nucleotide polymorphism is associated with isolated non-syndromic cleft palate but not with cleft lip with or without palate in South Indian population.
|
28712851 |
2018 |
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the mouse, loss of Irf6 or perturbation of Fgf signaling leads to abnormal oral epithelial adhesions and cleft palate.
|
28732181 |
2017 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While single heterozygous mice are normal, double heterozygous embryos (Irf6 <sup>+/-</sup> ; Twist1 <sup>+/-</sup> ) can have severe mandibular hypoplasia that leads to agnathia and cleft palate at birth.
|
28769044 |
2017 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of single-nucleotide polymorphisms, rs2235371 and rs2013162, in the IRF6 gene with non-syndromic cleft palate in northeast China.
|
27706679 |
2016 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association and Mutation Analyses of the IRF6 Gene in Families With Nonsyndromic and Syndromic Cleft Lip and/or Cleft Palate.
|
23394314 |
2014 |
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
IRF6 was also associated with cleft palate (CP) with impaction of permanent teeth (p<10(-6)).
|
23029012 |
2012 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the interferon regulatory factor 6 (IRF6) gene are known to cause van der Woude syndrome (VWS), a common syndromic form of oro-facial clefting characterized by the familial occurrence of mixed clefting (cleft lip with or without a cleft palate and cleft palate alone in the same family) and lower lip pits.
|
21082654 |
2010 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance.
|
20436469 |
2010 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in IRF6 cause Van der Woude syndrome (VWS), one of the most common syndromes associated with cleft lip (CL) with or without cleft palate (CP).
|
20184620 |
2010 |
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate.
|
20672350 |
2010 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate.
|
20652317 |
2010 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, we have demonstrated that mice homozygous for a mutation in Irf6 exhibit abnormalities of epithelial differentiation that results in cleft palate as a consequence of adhesion between the palatal shelves and the tongue.
|
19439425 |
2009 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further, results were phenotype dependent in that the IRF6 region results were most significant for families in which affected individuals have CL alone, and the FOXE1 region results were most significant in families in which some or all of the affected individuals have CL with CP.
|
19521098 |
2009 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population.
|
19115793 |
2009 |
Cleft palate, isolated
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarly, Irf6 was found to be down-regulated in the medial edge epithelia of transforming growth factor beta3-null mice, which also exhibit cleft palate.
|
16245336 |
2006 |
Cleft palate, isolated
|
0.400 |
Biomarker
|
disease |
CTD_human |
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6).
|
17041601 |
2006 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Van der Woude syndrome (VWS, OMIM 119300) is an autosomal dominant craniofacial disorder characterized by pits of the lower lip, hypodontia, and cleft lip and/or cleft palate.
|
12920575 |
2003 |
Cleft palate, isolated
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that a gene at 17p11.2-11.1, together with the VWS gene at 1p32-41, enhances the probability of CP in an individual carrying the two at-risk genes.
|
10417286 |
1999 |