Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PYCR1 interference could inhibit cell proliferation and promote cell apoptosis in HCC through regluting JNK/IRS1 pathway.
|
31619254 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggest that upregulated Irs1 by Wnt/β-catenin signaling plays a crucial role in the progression of HCC.
|
28710407 |
2017 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data provided convincing evidence that miR-384 exerted suppressive effect on HCC cell proliferation through the direct inhibition of IRS1 expression, suggesting miR-384 may serve as a potential therapeutic target for HCC.
|
27542674 |
2016 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling, implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC.
|
24690171 |
2014 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we demonstrated that miR-105 could deactivated the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway by downregulating insulin receptor substrate-1, 3-phosphoinositide-dependent protein kinase-1 and AKT1 directly, resulting in increasing cyclin-dependent kinase inhibitors 1A and 1B (p21(Cip1) and p27(Kip1)) and decreasing cyclin D1 expression in HCC.
|
25280563 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1.
|
23958494 |
2013 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We validated expression of 18 selected target genes involved in Wnt/β-catenin, insulin/IGF-1/IRS1 and Notch signalling pathways in 47 pairs of human HCCs and adjacent uninvolved liver tissues.
|
23651211 |
2013 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We measured the expression levels of insulin receptor substrate 1 (IRS-1), IRS-2, and other factors involved in the insulin signal pathway in a human hepatoma cell line (Huh-7) transiently expressing the HCV core protein of genotypes 3a or 1b by molecular biology and biochemical techniques.
|
17465001 |
2007 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We employed single (c-myc, SV40-Tag) and established double [insulin receptor substrate-1 (IRS-1/c-myc) and hepatitis Bx protein (X/c-myc)] transgenic lines and all developed HCC.
|
16098625 |
2005 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To determine if these substances are abnormally expressed under pathophysiologic conditions, IR, IRS-1, Grb2 protein, and IR mRNA were studied in normal human liver (n = 10), cirrhotic liver (n = 10), and hepatocellular carcinoma (HCC) (n = 10) that had been procured during operative procedures.
|
10210639 |
1999 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have found that approximately 40% of 22 human hepatocellular carcinoma (HCC) tumors had enhanced (>200%) hIRS-1 gene expression compared with adjacent non-involved liver tissue.
|
9303488 |
1997 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression and tyrosyl phosphorylation of IRS-1 play an important role during normal hepatocyte growth, and the gene is overexpressed in hepatocellular carcinoma tissue.
|
8622697 |
1996 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These investigations explored the effect of ethanol additions on the expression and tyrosyl phosphorylation (TP) of p36 and IRS-1 in a human hepatocellular carcinoma cell line (FOCUS) in relationship to cell proliferation induced by IN and serum growth factor stimulation.
|
7542850 |
1995 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Higher levels of hIRS-1 gene transcripts were observed in HCC tumors compared to adjacent non-involved normal liver.
|
1311924 |
1992 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Higher levels of hIRS-1 gene transcripts were observed in HCC tumors compared to adjacent non-involved normal liver.
|
1311924 |
1992 |