IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE According to the results of this study, the presence of AA genotype in both CCR5 and IRS1 is associated with type 2 diabetes. 30884193 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Background Previous genome-wide association studies (GWAS) identified IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). 30864372 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE In addition, the improvement of ER stress regulated the insulin signal transduction proteins, reducing p-IRS-1(ser) levels and increasing p-IRS-1(tyr) in GA-treated T2DM rats and IR HepG2 cells. 30864442 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Our findings suggest that the phosphorylation of IRS1 at specific Ser sites is a potential marker of Aβ-unrelated memory deficits caused by type 2 diabetes and aging; however, in Aβ-related memory decline, the modifications of IRS1 may be a marker of early detection of Aβ42 elevation prior to the onset of memory decline in AD. 31426549 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE In conclusion, association between rs1801278 polymorphism of the IRS-1 gene and insulin resistance in T2DM has been established in a Pakistani population. 31446532 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 PosttranslationalModification disease BEFREE On the other hand, the increased phosphorylation of IRS1 at several serine sites is observed in the brains from patients with AD and animal models of AD or cognitive impairment induced by type 2 diabetes. 30964050 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE In this study, we have identified three novel mutations in the IRS1 gene of type 2 diabetic (T2D) patients, which reflected in the amino acid changes as I65S, R66S, and G86R in the phosphotyrosine binding domain of the IRS1 protein. 31660472 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Western blot analysis indicated that the up-regulated IRS1-PI3K-Akt phosphorylation followed by the down-regulated FoxO1/GSK 3β phosphorylation contributed to the enhanced glycogen synthesis and the decreased gluconeogenesis by GXG, suggesting that the response of insulin-mediated IRS1-PI3K-Akt-FoxO1/GSK 3β signaling to GXG might be the required mechanism for GXG-ameliorated development of type 2 diabetes. 30824102 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Mitsugumin 53 (MG53 or TRIM72), a striated muscle-specific E3 ligase, promotes ubiquitin-dependent degradation of the insulin receptor and insulin receptor substrate-1 and subsequently induces insulin resistance, resulting in metabolic syndrome and type 2 diabetes mellitus (T2DM). 30586741 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Carriers of the PPARγ variant allele had statistically significantly lower rates of type 2 diabetes (P = 0.04), lower BMI (P = 0.01), and HOMA scores [P = 0.004; non-Hispanic White (NHWs) only]; carriers of the TNF-α variant A allele had higher serum glucose (P = 0.004, NHW only); and the IRS-1 variant was associated with higher leptin levels (P = 0.003, Hispanics only). 29256014 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE Exercise was protective against paternal HF-diet-induced insulin resistance by increasing the expression of insulin signaling (GLUT4, IRS1 and PI3K) markers in skeletal muscle resulting in normal T2D risk. 29669306 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE In all, though further studies are needed for confirming this finding, our present data point to IRS1 rs1801278 as a potential biomarker for pursuing the goal of stratified medicine in the field of antihyperglycemic treatment in T2D. 28696414 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE When compared with controls, the serum level of MCP-1, TNF-<i>α</i>, IL-6, IRS-1, and p-IRS-1 was significantly increased in T2DM rats, but the level of PKB, p-PKB, PI3Kp85, and p-PI3K expression was reduced (<i>P</i> < 0.05). 28458712 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Evidence in obesity and type-2 diabetes suggests a role for a metabolic inflammasome ("metaflammasome") in mediating chronic inflammation in peripheral organs implicating IKKβ (inhibitor of nuclear factor kappa-B kinase subunit beta), IRS1 (insulin receptor substrate 1), JNK (c-jun N-terminal kinase), and PKR (double-stranded RNA protein kinase). 27106634 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Furthermore, Western blot analysis revealed that T2DM rats had enhanced nuclear translocation of NF-κB as well as elevated phosphorylation of Ser307 in IRS-1(insulin receptor substrate 1). 28651236 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE Interestingly, delta like 1, peroxisome proliferator-activated receptor alpha, and interleukin 1β were upregulated whereas Sirtuin 1 and insulin receptor substrate 1 gene expression were found downregulated in dASC compared to cells obtained from healthy subjects. 27909015 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE These findings displayed the potential of WSZYF as a new drug candidate in the treatment of T2DM and the antidiabetic mechanism of WSZYF is probably mediated through modulating the PTP1B-IRS1-Akt-GLUT4 signaling pathway. 29479370 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE In obesity and type 2 diabetes, selective downregulation of Irs2 and its downstream actions to cause reduced insulin actions was associated with increased insulin actions through Irs1 in variety tissues. 28380373 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. 28440404 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.900 Biomarker disease BEFREE We conducted an exploratory analysis by testing whether common genetic variability at IRS1, ENPP1 and TRIB3 loci is associated with cardiovascular risk traits and metabolic phenotypes in T2DM. 26868433 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE Differential actıvation and expression of insulin receptor substrate 1 (IRS1) in mononuclear cells of type 2 diabetes patients after insulin stimulation. 26950447 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE We investigated the possible association between insulin receptor substrate-1 (IRS-1) polymorphisms and high platelet reactivity in coronary artery disease (CAD) patients with type 2 diabetes mellitus (T2DM). 27005817 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation disease BEFREE Associations between two single-nucleotide polymorphisms (rs1801278 and rs2943641) of insulin receptor substrate 1 gene and type 2 diabetes susceptibility: a meta-analysis. 26582067 2016
Diabetes Mellitus, Non-Insulin-Dependent
0.900 AlteredExpression disease BEFREE In conclusion, hyperglycemia may activate platelets through miR-144 and miR-223 to downregulate IRS-1 and upregulate P2Y12 expression in the platelets of T2DM patients through an IRS-1-PI3K-Akt signaling. 26175178 2016