AR, androgen receptor, 367

N. diseases: 854; N. variants: 163
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 GeneticVariation disease BEFREE Polymorphic CAG Repeat Numbers in the Androgen Receptor Gene of Female Pattern Hair Loss in a Han Chinese Population. 27304862 2016
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 Biomarker disease BEFREE It is known that baldness caused by androgenetic alopecia is involved with androgen and the androgen receptor. 23955654 2013
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 GeneticVariation disease BEFREE The discovery of the androgen receptor (AR) gene and related genes has expanded the knowledge on the genetics of hair loss. 21061765 2010
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 Biomarker disease BEFREE These results support the hypothesis that androgen-mediated hair loss is AR dependent and suggest that AR and beta-catenin mediate this effect. 20233794 2010
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 GeneticVariation disease BEFREE In 2001, we published the first significant evidence of a genetic association between baldness and a synonymous coding SNP (rs6152) in the androgen receptor gene, AR. 17256155 2007
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 Biomarker disease CTD_human Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. 15902657 2005
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 GeneticVariation disease BEFREE These results suggest that the AR-E211 A allele, in linkage with the functional repeat sequences, is associated with a lower risk of metastatic prostate cancer and a lower risk of alopecia. 15824176 2005
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 Biomarker disease BEFREE Also, after the topical treatment with TOS extract and androgen receptor antagonist (cyproterone acetate) simultaneously with subcutaneous injection of testosterone (1 mg/mice/day), hair loss patterns of female B6CBAF1/j hybrid mouse were observed. 12670719 2003
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 GeneticVariation disease BEFREE To determine if the androgen receptor gene is associated with male pattern baldness, we compared allele frequencies of the androgen receptor gene polymorphisms (StuI restriction fragment length polymorphism and two triplet repeat polymorphisms) in cases with cosmetically significant baldness (54 young and 392 older men) and controls (107 older men) with no indication of baldness. 11231320 2001
CUI: C0002170
Disease: Alopecia
Alopecia
0.390 Biomarker disease BEFREE Although CAIS is the best known phenotype, recent studies from our laboratory and elsewhere show that malfunction of the AR is associated with many androgen-regulated diseases or conditions that cross traditional clinical disciplines ranging from paediatrics (ambiguous genitalia), gynaecology (primary amenorrhoea), urology (prostate cancer), neurology (spinal bulbar muscular atrophy), reproductive medicine (male infertility), orthopedics (rheumatoid arthritis), oncology (breast cancer) and dermatology (hirsutism, baldness and acne). 10711573 2000