|
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of androgen receptor and 5α-reductase 2, along with upregulation of 5α-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice.
|
28493878 |
2017 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The objective of the study was to evaluate and compare the androgen receptor (AR) expression in benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and prostatic adenocarcinoma.
|
27072221 |
2016 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, 83% of mice with PIN lesions exhibited metastases to draining lymph nodes, marked by relatively differentiated tumor cells expressing markers of basal (p63, cytokeratin 14) and luminal (cytokeratin 8 and androgen receptor) epithelial cells, although none expressed the basal marker, cytokeratin 5.
|
24492704 |
2014 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
(iv) Reduced PIN formation by metformin was associated with reduced levels of androgen receptor and proliferation marker Ki-67 in Hi-Myc mouse prostate glands.
|
24130167 |
2013 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate a selective role for AR in the initiation of PIN, dependent on the signaling pathways driving tumor formation.
|
21518863 |
2011 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
CTD_human |
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
|
20601956 |
2010 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
BEFREE |
Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81.
|
19789348 |
2009 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression profiling using microarrays, which was selectively validated and extended by immunophenotyping of Neu*-induced PIN and CAP, led to the identification of some novel biomarkers and also revealed increased expression of Egfr, Erbb3 and phosphorylated androgen receptor.
|
16401639 |
2006 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
LHGDN |
In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors.
|
14743468 |
2004 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The methylation status of 7 genes was examined in four cell lines, 36 samples of benign prostatic hyperplasia (BPH), 20 samples of prostatic intraepithelial neoplasia (PIN) and 109 samples of prostate cancer (PCa), using methylation-specific PCR (MSP): the pi-class glutathione S-transferase (GSTP1), retinoic acid receptor beta 2(RARbeta2), androgen receptor (AR), death-associated protein kinase (DAPK), tissue inhibitor of metalloproteinase-3 (TIMP-3), O(6)-methylguanine DNA methyltransferase (MGMT), and hypermethylated in cancer-1 (HIC-1).
|
12845678 |
2003 |
|
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Androgen receptor expression in prostatic dysplasia (prostatic intraepithelial neoplasia) in the human prostate: an immunohistochemical and in situ hybridization study.
|
8827081 |
1996 |