|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
JAK2 rs1159782 (T>C) was also strongly associated with Crohn's disease (P = 2.34 × 10<sup>-4</sup> ; odds ratio = 3.72).
|
29441677 |
2018 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A mutated and dysregulated form of JAK2, a tyrosine kinase, is associated with several diseases including Crohn's disease.
|
25463744 |
2015 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicated that JAK2 rs10758669 polymorphism was a risk factor both for CD and UC, especially in Caucasian.
|
24385239 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FOS, UBE2L3, the JAK2 gene region, and rs1297265 at chromosome arm 21q21.1 likely play a role in both Crohn's disease and UC.
|
23511034 |
2013 |
|
Crohn Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Additionally, the mRNA and protein expression of JAK2 and IL-23R were increased in UC and Crohn's disease (CD) patients.
|
24382939 |
2013 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Data on genetic interaction reveals that the above JAK2 and STAT3 risk alleles contribute to CD susceptibility in combination with each other (OR: 2.218; 95% CI: 1.097-4.487; P = 0.024), while the JAK2 variant shows a tendency to confer UC risk only on a wild-type STAT3 background (OR: 1.997, 95%CI: 0.994-4.009, P = 0.049).
|
22269120 |
2012 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data confirm the association between JAK2 rs10758669 (p = 0.026, OR = 1.25, 95% CI = 1.04-1.50) and STAT3 rs744166 (p = 0.04, OR = 0.83, 95% CI = 0.688-0.998) with CD, but not UC.
|
22065112 |
2012 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Except rs10975003 from the JAK2 locus, none showed positive association with Crohn's disease.
|
21831733 |
2011 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the JAK2 rs10758669 polymorphism, the homozygous C/C or heterozygous A/C genotypes increased the risk of having CD as compared with the homozygous A/A (OR=1.76, 95% CI=1.26-2.45 and OR=2.36, 95% CI=1.44-3.86, respectively, p=0.0003).
|
20109474 |
2010 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies indicate that IL23R and five additional genes involved in Th17 differentiation (IL12B, JAK2, STAT3, CCR6 and TNFSF15) are associated with susceptibility to Crohn's disease and partly also to ulcerative colitis.
|
19592695 |
2009 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
|
18587394 |
2008 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|