Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These mutations include JAK2, CALR and MPL mutations as the main disease drivers, mutations driving clonal expansion, and mutations that contribute to progression of chronic MPNs to myelodysplasia and acute leukemia.
|
31741139 |
2020 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A high JAK2(V617F) allele burden was correlated with the transformation to myelofibrosis (p<0.0001), but not with the transformation to acute leukemia.
|
22818858 |
2013 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
More recently, aberrations involving the JAK2 gene have also been reported in lymphoid diseases, including acute leukemia and lymphomas.
|
23991929 |
2013 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to detect whether any association exists between genetic polymorphisms in JAK2 gene and individual susceptibility to acute leukemia.
|
22168550 |
2012 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the JAK2 locus are of oncogenic importance in acute leukemias, myelodysplastic/myeloproliferative diseases and T-cell lymphomas.
|
21091042 |
2011 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
JAK2 V617F mutation was detected after transformation to CMML in 1 of them; in the other, a novel translocation t(5;12)(p13;q24) was observed at the time of progression to acute leukemia.
|
21658659 |
2011 |
Acute leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, less common aberrations (particularly gene fusions) involving JAK2 have been described in acute leukemias.
|
18618714 |
2008 |
Acute leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just Another Kinase 2) play a central role in the pathogenesis of clinically and morphologically distinct chronic myeloproliferative disorders but are also found in some cases of de novo acute leukemia and lymphoma.
|
18528425 |
2008 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
ETV6-JAK2, PCM1-JAK2, BCR-JAK2) mutations have respectively been described in acute megakaryocytic leukemia and acute leukemia/chronic myeloid malignancies.
|
18297515 |
2008 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite this progress, many questions remain unsolved, including how a single JAK2 mutation causes three different MPD phenotypes, what other genes might be involved in the pathogenesis, and what are the factors determining the progression to acute leukemia.
|
18024602 |
2007 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We focused our study on the Janus kinase 2 (JAK2) gene in 90 cases of acute leukemia.
|
17068151 |
2007 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders.
|
17077140 |
2006 |
Acute leukemia
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
|
16037387 |
2005 |
Acute leukemia
|
0.200 |
Biomarker
|
disease |
BEFREE |
A translocation generating the constitutively activated fusion protein PCM1-JAK2 has also been recently found in atypical chronic myelogenous leukemia and acute leukemia.
|
16007127 |
2005 |
Acute leukemia
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|