JAK2, Janus kinase 2, 3717

N. diseases: 644; N. variants: 54
Disease: Myocardial Ischemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 Biomarker disease BEFREE Protective effects of N(2)‑L‑alanyl‑L‑glutamine mediated by the JAK2/STAT3 signaling pathway on myocardial ischemia reperfusion. 29393473 2018
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 AlteredExpression disease BEFREE Eriodictyol Attenuates Myocardial Ischemia-Reperfusion Injury through the Activation of JAK2. 29441020 2018
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 AlteredExpression disease BEFREE Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway. 29039526 2017
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 GeneticVariation disease BEFREE JAK2 V617F somatic mutation positives versus negatives had higher erythrocyte (P = 2 × 10(-5) ), thrombocyte (P = 2 × 10(-16) ), and leucocyte (P = 4 × 10(-9) ) counts, and had 2·7-/2·5-fold risk of cancer (prevalent/incident), 44-/28-fold risk of haematological cancer, 221-/97-fold risk of myeloproliferative cancer, 2·2-/1·2-fold risk of ischaemic heart disease, and 3·1-/1·0-fold risk of venous thromboembolism. 23116358 2013
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 Biomarker disease CTD_human Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury. 15746188 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.340 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005