|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The number of expressed CT genes was significantly higher in seminomas (P = 3.48 × 10<sup>-13</sup> ) which were characterized by frequent mutations in driver genes (KIT, KRAS and NRAS).
|
31070303 |
2019 |
|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Activating c-KIT mutations (exons 11 and 17) are found in 10-40% of testicular seminomas, the majority being missense point mutations (codon 816).
|
22937135 |
2012 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This study shows that expression of p53, Ki67, and CD30 and loss of CD117 expression fail to predict the presence of clinical metastasis at diagnosis of testicular seminoma and do not correlate with other histopathological risk factors in clinical stage I patients.
|
20881837 |
2011 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mutations and protein expression of KIT and PDGFRA genes in ipsilateral testicular seminomas: an immunohistochemical and molecular genetic study.
|
21403518 |
2011 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, protein expression of OCT3/4 and AP2y was weak and these JKT-1 cells expressed SOX2, a marker of embryonal carcinoma and did not express c-KIT usually expressed in most seminoma.
|
19226408 |
2010 |
|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature.
|
17943970 |
2008 |
|
Seminoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overexpression of KIT, a tyrosine kinase receptor protein encoded by the proto-oncogene c-kit, is observed in human neoplasms such as gastrointestinal stromal tumors (GISTs), myeloproliferative disorders, melanoma and seminoma.
|
18486988 |
2008 |
|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
c-KIT is mutated in some seminomas and bilateral germ cell tumors.
|
18363516 |
2008 |
|
Seminoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, DOG1.1 immunoreactivity was seen in fewer cases of carcinoma, melanoma, and seminoma as compared with KIT.
|
18223323 |
2008 |
|
Seminoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In order to assess a role for KIT in seminomas, we modulated the level of KIT expression in TCam-2, a seminoma cell line.
|
17573850 |
2007 |
|
Seminoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together with activating mutations of KIT in exon 17 identified in 13% of seminomas, this suggests that the KIT gene product plays a role in the progression of CIS towards seminoma, the further understanding of which may lead to novel less toxic therapeutic approaches.
|
16166280 |
2005 |
|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Biochemical evidence of KIT activation, as assessed by KIT phosphorylation and KIT association with phosphatidylinositol (PI) 3-kinase in tumor cell lysates, was largely confined to seminomas with a genomic KIT mutation.
|
14695343 |
2004 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
KIT tyrosine kinase is crucial for normal germ-cell development, and its expression is observed in the majority of seminomas and dysgerminomas.
|
15455230 |
2004 |
|
Seminoma
|
0.400 |
SomaticCausalMutation
|
disease |
ORPHANET |
Biochemical evidence of KIT activation, as assessed by KIT phosphorylation and KIT association with phosphatidylinositol (PI) 3-kinase in tumor cell lysates, was largely confined to seminomas with a genomic KIT mutation.
|
14695343 |
2004 |
|
Seminoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among human testicular germ cell tumors (GCTs), seminomas and seminoma components of mixed GCTs have also been shown to express KIT, but only one study has found the c-kit gene mutation at exon 17 in seminoma.
|
12824871 |
2003 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Primary mediastinal seminomas: evidence of single and multiple KIT mutations.
|
12379771 |
2002 |
|
Seminoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data obtained in both groups did not differ in any of the investigated biologic markers. c-KIT was detected in the one case of pure seminoma studied and in the seminomatous components of combined tumors.
|
12124830 |
2002 |
|
Seminoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The c-kit gene encodes a tyrosine kinase receptor (KIT) that is required in normal spermatogenesis and is expressed in seminomas and dysgerminomas, a subset of human germ cell tumors (GCTs).
|
10362788 |
1999 |